RNA sensor MDA5 suppresses LINE-1 retrotransposition by regulating the promoter activity of LINE-1 5′-UTR

BACKGROUND: Type 1 long interspersed elements, or LINE-1, are the only retroelements that replicate autonomously in human cells. The retrotransposition process of LINE-1 can trigger the activation of the innate immune system and has been proposed to play a role in the development of several autoimmu...

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Detalles Bibliográficos
Autores principales: Yan, Jiaxiu, Zhao, Yifei, Du, Juan, Wang, Yu, Wang, Shaohua, Wang, Qing, Zhao, Xu, Xu, Wei, Zhao, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003951/
https://www.ncbi.nlm.nih.gov/pubmed/35414110
http://dx.doi.org/10.1186/s13100-022-00268-0

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