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Plasma disappearance rate of albumin when infused as a 20% solution

BACKGROUND: The transcapillary leakage of albumin is increased by inflammation and major surgery, but whether exogenous albumin also disappears faster is unclear. METHODS: An intravenous infusion of 3 mL/kg of 20% albumin was given over 30 min to 70 subjects consisting of 15 healthy volunteers, 15 p...

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Autores principales: Zdolsek, Markus, Wuethrich, Patrick Y., Gunnström, Michaela, Zdolsek, Joachim H., Hasselgren, Emma, Beilstein, Christian M., Engel, Dominique, Hahn, Robert G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003982/
https://www.ncbi.nlm.nih.gov/pubmed/35410365
http://dx.doi.org/10.1186/s13054-022-03979-1
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author Zdolsek, Markus
Wuethrich, Patrick Y.
Gunnström, Michaela
Zdolsek, Joachim H.
Hasselgren, Emma
Beilstein, Christian M.
Engel, Dominique
Hahn, Robert G.
author_facet Zdolsek, Markus
Wuethrich, Patrick Y.
Gunnström, Michaela
Zdolsek, Joachim H.
Hasselgren, Emma
Beilstein, Christian M.
Engel, Dominique
Hahn, Robert G.
author_sort Zdolsek, Markus
collection PubMed
description BACKGROUND: The transcapillary leakage of albumin is increased by inflammation and major surgery, but whether exogenous albumin also disappears faster is unclear. METHODS: An intravenous infusion of 3 mL/kg of 20% albumin was given over 30 min to 70 subjects consisting of 15 healthy volunteers, 15 post-burn patients, 15 patients who underwent surgery with minor bleeding, 10 who underwent surgery with major bleeding (mean, 1.1 L) and 15 postoperative patients. Blood Hb and plasma albumin were measured on 15 occasions over 5 h. The rate of albumin disappearance from the plasma was quantitated with population kinetic methodology and reported as the half-life (T(1/2)). RESULTS: No differences were observed for T(1/2) between volunteers, post-burn patients, patients who underwent surgery with minor bleeding and postoperative patients. The T(1/2) averaged 16.2 h, which corresponds to 3.8% of the amount infused per h. Two groups showed plasma concentrations of C-reactive protein of approximately 60 mg/L and still had a similarly long T(1/2) for albumin. By contrast, patients undergoing surgery associated with major hemorrhage had a shorter T(1/2), corresponding to 15% of the infused albumin per h. In addition, our analyses show that the T(1/2) differ greatly depending on whether the calculations consider plasma volume changes and blood losses. CONCLUSION: The disappearance rate of the albumin in 20% preparations was low in volunteers, in patients with moderately severe inflammation, and in postoperative patients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13054-022-03979-1.
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spelling pubmed-90039822022-04-13 Plasma disappearance rate of albumin when infused as a 20% solution Zdolsek, Markus Wuethrich, Patrick Y. Gunnström, Michaela Zdolsek, Joachim H. Hasselgren, Emma Beilstein, Christian M. Engel, Dominique Hahn, Robert G. Crit Care Perspective BACKGROUND: The transcapillary leakage of albumin is increased by inflammation and major surgery, but whether exogenous albumin also disappears faster is unclear. METHODS: An intravenous infusion of 3 mL/kg of 20% albumin was given over 30 min to 70 subjects consisting of 15 healthy volunteers, 15 post-burn patients, 15 patients who underwent surgery with minor bleeding, 10 who underwent surgery with major bleeding (mean, 1.1 L) and 15 postoperative patients. Blood Hb and plasma albumin were measured on 15 occasions over 5 h. The rate of albumin disappearance from the plasma was quantitated with population kinetic methodology and reported as the half-life (T(1/2)). RESULTS: No differences were observed for T(1/2) between volunteers, post-burn patients, patients who underwent surgery with minor bleeding and postoperative patients. The T(1/2) averaged 16.2 h, which corresponds to 3.8% of the amount infused per h. Two groups showed plasma concentrations of C-reactive protein of approximately 60 mg/L and still had a similarly long T(1/2) for albumin. By contrast, patients undergoing surgery associated with major hemorrhage had a shorter T(1/2), corresponding to 15% of the infused albumin per h. In addition, our analyses show that the T(1/2) differ greatly depending on whether the calculations consider plasma volume changes and blood losses. CONCLUSION: The disappearance rate of the albumin in 20% preparations was low in volunteers, in patients with moderately severe inflammation, and in postoperative patients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13054-022-03979-1. BioMed Central 2022-04-11 /pmc/articles/PMC9003982/ /pubmed/35410365 http://dx.doi.org/10.1186/s13054-022-03979-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Perspective
Zdolsek, Markus
Wuethrich, Patrick Y.
Gunnström, Michaela
Zdolsek, Joachim H.
Hasselgren, Emma
Beilstein, Christian M.
Engel, Dominique
Hahn, Robert G.
Plasma disappearance rate of albumin when infused as a 20% solution
title Plasma disappearance rate of albumin when infused as a 20% solution
title_full Plasma disappearance rate of albumin when infused as a 20% solution
title_fullStr Plasma disappearance rate of albumin when infused as a 20% solution
title_full_unstemmed Plasma disappearance rate of albumin when infused as a 20% solution
title_short Plasma disappearance rate of albumin when infused as a 20% solution
title_sort plasma disappearance rate of albumin when infused as a 20% solution
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003982/
https://www.ncbi.nlm.nih.gov/pubmed/35410365
http://dx.doi.org/10.1186/s13054-022-03979-1
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