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DNA methylation regulates TIGIT expression within the melanoma microenvironment, is prognostic for overall survival, and predicts progression-free survival in patients treated with anti-PD-1 immunotherapy

BACKGROUND: TIGIT is an immune checkpoint under investigation as therapeutic target. Understanding the regulation of TIGIT on an epigenetic level might support the development of companion biomarkers. METHODS: We correlated TIGIT DNA methylation of single CpG sites with gene expression, signatures o...

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Detalles Bibliográficos
Autores principales:	Niebel, Dennis, Fröhlich, Anne, Zarbl, Romina, Fietz, Simon, de Vos, Luka, Vogt, Timo J., Dietrich, Jörn, Sirokay, Judith, Kuster, Pia, Saavedra, Gonzalo, Ramírez Valladolid, Susana, Hoffmann, Friederike, Strieth, Sebastian, Landsberg, Jennifer, Dietrich, Dimo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004005/ https://www.ncbi.nlm.nih.gov/pubmed/35410311 http://dx.doi.org/10.1186/s13148-022-01270-2

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