The implications of exosomes in pregnancy: emerging as new diagnostic markers and therapeutics targets

Extracellular vehicles (EVs) are a heterogeneous group of cell and membranous particles originating from different cell compartments. EVs participate in many essential physiological functions and mediate fetal-maternal communications. Exosomes are the smallest unit of EVs, which are delivered to the...

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Autores principales: Ghafourian, Mehri, Mahdavi, Roya, Akbari Jonoush, Zahra, Sadeghi, Mahvash, Ghadiri, Nooshin, Farzaneh, Maryam, Mousavi Salehi, Abdolah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004059/
https://www.ncbi.nlm.nih.gov/pubmed/35414084
http://dx.doi.org/10.1186/s12964-022-00853-z
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author Ghafourian, Mehri
Mahdavi, Roya
Akbari Jonoush, Zahra
Sadeghi, Mahvash
Ghadiri, Nooshin
Farzaneh, Maryam
Mousavi Salehi, Abdolah
author_facet Ghafourian, Mehri
Mahdavi, Roya
Akbari Jonoush, Zahra
Sadeghi, Mahvash
Ghadiri, Nooshin
Farzaneh, Maryam
Mousavi Salehi, Abdolah
author_sort Ghafourian, Mehri
collection PubMed
description Extracellular vehicles (EVs) are a heterogeneous group of cell and membranous particles originating from different cell compartments. EVs participate in many essential physiological functions and mediate fetal-maternal communications. Exosomes are the smallest unit of EVs, which are delivered to the extracellular space. Exosomes can be released by the umbilical cord, placenta, amniotic fluid, and amniotic membranes and are involved in angiogenesis, endothelial cell migration, and embryo implantation. Also, various diseases such as gestational hypertension, gestational diabetes mellitus (GDM), preterm birth, and fetal growth restriction can be related to the content of placental exosomes during pregnancy. Due to exosomes' ability to transport signaling molecules and their effect on sperm function, they can also play a role in male and female infertility. In the new insight, exosomal miRNA can diagnose and treat infertilities disorders. In this review, we focused on the functions of exosomes during pregnancy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-022-00853-z.
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spelling pubmed-90040592022-04-13 The implications of exosomes in pregnancy: emerging as new diagnostic markers and therapeutics targets Ghafourian, Mehri Mahdavi, Roya Akbari Jonoush, Zahra Sadeghi, Mahvash Ghadiri, Nooshin Farzaneh, Maryam Mousavi Salehi, Abdolah Cell Commun Signal Review Extracellular vehicles (EVs) are a heterogeneous group of cell and membranous particles originating from different cell compartments. EVs participate in many essential physiological functions and mediate fetal-maternal communications. Exosomes are the smallest unit of EVs, which are delivered to the extracellular space. Exosomes can be released by the umbilical cord, placenta, amniotic fluid, and amniotic membranes and are involved in angiogenesis, endothelial cell migration, and embryo implantation. Also, various diseases such as gestational hypertension, gestational diabetes mellitus (GDM), preterm birth, and fetal growth restriction can be related to the content of placental exosomes during pregnancy. Due to exosomes' ability to transport signaling molecules and their effect on sperm function, they can also play a role in male and female infertility. In the new insight, exosomal miRNA can diagnose and treat infertilities disorders. In this review, we focused on the functions of exosomes during pregnancy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-022-00853-z. BioMed Central 2022-04-12 /pmc/articles/PMC9004059/ /pubmed/35414084 http://dx.doi.org/10.1186/s12964-022-00853-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Ghafourian, Mehri
Mahdavi, Roya
Akbari Jonoush, Zahra
Sadeghi, Mahvash
Ghadiri, Nooshin
Farzaneh, Maryam
Mousavi Salehi, Abdolah
The implications of exosomes in pregnancy: emerging as new diagnostic markers and therapeutics targets
title The implications of exosomes in pregnancy: emerging as new diagnostic markers and therapeutics targets
title_full The implications of exosomes in pregnancy: emerging as new diagnostic markers and therapeutics targets
title_fullStr The implications of exosomes in pregnancy: emerging as new diagnostic markers and therapeutics targets
title_full_unstemmed The implications of exosomes in pregnancy: emerging as new diagnostic markers and therapeutics targets
title_short The implications of exosomes in pregnancy: emerging as new diagnostic markers and therapeutics targets
title_sort implications of exosomes in pregnancy: emerging as new diagnostic markers and therapeutics targets
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004059/
https://www.ncbi.nlm.nih.gov/pubmed/35414084
http://dx.doi.org/10.1186/s12964-022-00853-z
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