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VCP suppresses proteopathic seeding in neurons

BACKGROUND: Neuronal uptake and subsequent spread of proteopathic seeds, such as αS (alpha-synuclein), Tau, and TDP-43, contribute to neurodegeneration. The cellular machinery participating in this process is poorly understood. One proteinopathy called multisystem proteinopathy (MSP) is associated w...

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Detalles Bibliográficos
Autores principales:	Zhu, Jiang, Pittman, Sara, Dhavale, Dhruva, French, Rachel, Patterson, Jessica N., Kaleelurrrahuman, Mohamed Salman, Sun, Yuanzi, Vaquer-Alicea, Jaime, Maggiore, Gianna, Clemen, Christoph S., Buscher, William J., Bieschke, Jan, Kotzbauer, Paul, Ayala, Yuna, Diamond, Marc I., Davis, Albert A., Weihl, Conrad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004082/ https://www.ncbi.nlm.nih.gov/pubmed/35414105 http://dx.doi.org/10.1186/s13024-022-00532-0

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