Growth factor independence underpins a paroxysmal, aggressive Wnt5a(High)/EphA2(Low) phenotype in glioblastoma stem cells, conducive to experimental combinatorial therapy

BACKGROUND: Glioblastoma multiforme (GBM) is an incurable tumor, with a median survival rate of only 14–15 months. Along with heterogeneity and unregulated growth, a central matter in dealing with GBMs is cell invasiveness. Thus, improving prognosis requires finding new agents to inhibit key multipl...

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Detalles Bibliográficos
Autores principales: Trivieri, Nadia, Visioli, Alberto, Mencarelli, Gandino, Cariglia, Maria Grazia, Marongiu, Laura, Pracella, Riccardo, Giani, Fabrizio, Soriano, Amata Amy, Barile, Chiara, Cajola, Laura, Copetti, Massimiliano, Palumbo, Orazio, Legnani, Federico, DiMeco, Francesco, Gorgoglione, Leonardo, Vescovi, Angelo L., Binda, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004109/
https://www.ncbi.nlm.nih.gov/pubmed/35414102
http://dx.doi.org/10.1186/s13046-022-02333-1

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