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Fabrication of subunit nanovaccines by physical interaction

Vaccines can improve the quality of human life by preventing the burden of infectious diseases. Also, vaccination is becoming a powerful medication for preventing and treating tumors. Various vaccines have been developed based on the origin of the antigens. Herein, we focus on the subunit vaccines w...

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Detalles Bibliográficos
Autores principales: Chen, HaoLin, Liu, Hong, Liu, LiXin, Chen, YongMing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Science China Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004205/
https://www.ncbi.nlm.nih.gov/pubmed/35432491
http://dx.doi.org/10.1007/s11431-021-2011-7
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author Chen, HaoLin
Liu, Hong
Liu, LiXin
Chen, YongMing
author_facet Chen, HaoLin
Liu, Hong
Liu, LiXin
Chen, YongMing
author_sort Chen, HaoLin
collection PubMed
description Vaccines can improve the quality of human life by preventing the burden of infectious diseases. Also, vaccination is becoming a powerful medication for preventing and treating tumors. Various vaccines have been developed based on the origin of the antigens. Herein, we focus on the subunit vaccines whose antigens are proteins or peptides. The advantage of subunit vaccines is safety for recipients; however, the immunogenicity of subunit antigens is relatively low. Nanoparticular delivery systems have been applied to improve the immunocompetence of subunit vaccines by targeting lymph nodes, and effectively present antigens to immune cells. Moreover, adding appropriate molecular adjuvants may strengthen the antigens to elicit immune response. In this perspective article, we first elucidate the characteristics of immunity induced by subunit nanovaccines and then summarize the strategies to fabricate subunit nanovaccines with delivering materials. Herein we highlight non-covalent interaction to fabricate nanoparticular subunit vaccines.
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spelling pubmed-90042052022-04-12 Fabrication of subunit nanovaccines by physical interaction Chen, HaoLin Liu, Hong Liu, LiXin Chen, YongMing Sci China Technol Sci Review Vaccines can improve the quality of human life by preventing the burden of infectious diseases. Also, vaccination is becoming a powerful medication for preventing and treating tumors. Various vaccines have been developed based on the origin of the antigens. Herein, we focus on the subunit vaccines whose antigens are proteins or peptides. The advantage of subunit vaccines is safety for recipients; however, the immunogenicity of subunit antigens is relatively low. Nanoparticular delivery systems have been applied to improve the immunocompetence of subunit vaccines by targeting lymph nodes, and effectively present antigens to immune cells. Moreover, adding appropriate molecular adjuvants may strengthen the antigens to elicit immune response. In this perspective article, we first elucidate the characteristics of immunity induced by subunit nanovaccines and then summarize the strategies to fabricate subunit nanovaccines with delivering materials. Herein we highlight non-covalent interaction to fabricate nanoparticular subunit vaccines. Science China Press 2022-04-08 2022 /pmc/articles/PMC9004205/ /pubmed/35432491 http://dx.doi.org/10.1007/s11431-021-2011-7 Text en © Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review
Chen, HaoLin
Liu, Hong
Liu, LiXin
Chen, YongMing
Fabrication of subunit nanovaccines by physical interaction
title Fabrication of subunit nanovaccines by physical interaction
title_full Fabrication of subunit nanovaccines by physical interaction
title_fullStr Fabrication of subunit nanovaccines by physical interaction
title_full_unstemmed Fabrication of subunit nanovaccines by physical interaction
title_short Fabrication of subunit nanovaccines by physical interaction
title_sort fabrication of subunit nanovaccines by physical interaction
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004205/
https://www.ncbi.nlm.nih.gov/pubmed/35432491
http://dx.doi.org/10.1007/s11431-021-2011-7
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