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Fabrication of subunit nanovaccines by physical interaction
Vaccines can improve the quality of human life by preventing the burden of infectious diseases. Also, vaccination is becoming a powerful medication for preventing and treating tumors. Various vaccines have been developed based on the origin of the antigens. Herein, we focus on the subunit vaccines w...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Science China Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004205/ https://www.ncbi.nlm.nih.gov/pubmed/35432491 http://dx.doi.org/10.1007/s11431-021-2011-7 |
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author | Chen, HaoLin Liu, Hong Liu, LiXin Chen, YongMing |
author_facet | Chen, HaoLin Liu, Hong Liu, LiXin Chen, YongMing |
author_sort | Chen, HaoLin |
collection | PubMed |
description | Vaccines can improve the quality of human life by preventing the burden of infectious diseases. Also, vaccination is becoming a powerful medication for preventing and treating tumors. Various vaccines have been developed based on the origin of the antigens. Herein, we focus on the subunit vaccines whose antigens are proteins or peptides. The advantage of subunit vaccines is safety for recipients; however, the immunogenicity of subunit antigens is relatively low. Nanoparticular delivery systems have been applied to improve the immunocompetence of subunit vaccines by targeting lymph nodes, and effectively present antigens to immune cells. Moreover, adding appropriate molecular adjuvants may strengthen the antigens to elicit immune response. In this perspective article, we first elucidate the characteristics of immunity induced by subunit nanovaccines and then summarize the strategies to fabricate subunit nanovaccines with delivering materials. Herein we highlight non-covalent interaction to fabricate nanoparticular subunit vaccines. |
format | Online Article Text |
id | pubmed-9004205 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Science China Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-90042052022-04-12 Fabrication of subunit nanovaccines by physical interaction Chen, HaoLin Liu, Hong Liu, LiXin Chen, YongMing Sci China Technol Sci Review Vaccines can improve the quality of human life by preventing the burden of infectious diseases. Also, vaccination is becoming a powerful medication for preventing and treating tumors. Various vaccines have been developed based on the origin of the antigens. Herein, we focus on the subunit vaccines whose antigens are proteins or peptides. The advantage of subunit vaccines is safety for recipients; however, the immunogenicity of subunit antigens is relatively low. Nanoparticular delivery systems have been applied to improve the immunocompetence of subunit vaccines by targeting lymph nodes, and effectively present antigens to immune cells. Moreover, adding appropriate molecular adjuvants may strengthen the antigens to elicit immune response. In this perspective article, we first elucidate the characteristics of immunity induced by subunit nanovaccines and then summarize the strategies to fabricate subunit nanovaccines with delivering materials. Herein we highlight non-covalent interaction to fabricate nanoparticular subunit vaccines. Science China Press 2022-04-08 2022 /pmc/articles/PMC9004205/ /pubmed/35432491 http://dx.doi.org/10.1007/s11431-021-2011-7 Text en © Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Chen, HaoLin Liu, Hong Liu, LiXin Chen, YongMing Fabrication of subunit nanovaccines by physical interaction |
title | Fabrication of subunit nanovaccines by physical interaction |
title_full | Fabrication of subunit nanovaccines by physical interaction |
title_fullStr | Fabrication of subunit nanovaccines by physical interaction |
title_full_unstemmed | Fabrication of subunit nanovaccines by physical interaction |
title_short | Fabrication of subunit nanovaccines by physical interaction |
title_sort | fabrication of subunit nanovaccines by physical interaction |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004205/ https://www.ncbi.nlm.nih.gov/pubmed/35432491 http://dx.doi.org/10.1007/s11431-021-2011-7 |
work_keys_str_mv | AT chenhaolin fabricationofsubunitnanovaccinesbyphysicalinteraction AT liuhong fabricationofsubunitnanovaccinesbyphysicalinteraction AT liulixin fabricationofsubunitnanovaccinesbyphysicalinteraction AT chenyongming fabricationofsubunitnanovaccinesbyphysicalinteraction |