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Shape shifting: The multiple conformational substates of the PTEN N‐terminal PIP(2) ‐binding domain

The Phosphatase and TENsin homolog deleted on chromosome 10 (PTEN) is a chief regulator of a variety of cellular processes including cell proliferation, migration, growth, and death. It is also a major tumor suppressor gene that is frequently mutated or lost under cancerous conditions. PTEN encodes...

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Detalles Bibliográficos
Autores principales: Dawson, Jennifer E., Smith, Iris Nira, Martin, William, Khan, Krishnendu, Cheng, Feixiong, Eng, Charis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004235/
https://www.ncbi.nlm.nih.gov/pubmed/35481646
http://dx.doi.org/10.1002/pro.4308