Cargando…

Shape shifting: The multiple conformational substates of the PTEN N‐terminal PIP(2) ‐binding domain

The Phosphatase and TENsin homolog deleted on chromosome 10 (PTEN) is a chief regulator of a variety of cellular processes including cell proliferation, migration, growth, and death. It is also a major tumor suppressor gene that is frequently mutated or lost under cancerous conditions. PTEN encodes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dawson, Jennifer E., Smith, Iris Nira, Martin, William, Khan, Krishnendu, Cheng, Feixiong, Eng, Charis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2022
Materias:	Accelerated Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004235/ https://www.ncbi.nlm.nih.gov/pubmed/35481646 http://dx.doi.org/10.1002/pro.4308

Ejemplares similares

Structural and Dynamic Effects of PTEN C-Terminal Tail Phosphorylation
por: Smith, Iris N., et al.
Publicado: (2022)

The mechanism of full activation of tumor suppressor PTEN at the phosphoinositide-enriched membrane
por: Jang, Hyunbum, et al.
Publicado: (2021)

PTEN interacts with RNA polymerase II to dephosphorylate polymerase II C-terminal domain
por: Abbas, Ata, et al.
Publicado: (2019)

Analysing the visible conformational substates of the FK506-binding protein FKBP12
por: Mustafi, Sourajit M., et al.
Publicado: (2013)

Impact of Conformational Substates and Energy Landscapes on Understanding Hemoglobin Kinetics and Function
por: Eaton, William A.
Publicado: (2021)

Conformational Substates of Myoglobin Intermediate Resolved by Picosecond X-ray Solution Scattering
por: Oang, Key Young, et al.
Publicado: (2014)

Gas insulated substations
por: Koch, Hermann
Publicado: (2014)

The bacterial and mitochondrial ribosomal A-site molecular switches possess different conformational substates
por: Kondo, Jiro, et al.
Publicado: (2008)

An Identification Method for Irregular Components Related to Terminal Blocks in Equipment Cabinet of Power Substation
por: Cao, Weiguo, et al.
Publicado: (2023)

Single-molecule visualization determines conformational substate ensembles in β-sheet–rich peptide fibrils
por: Zhang, Wenbo, et al.
Publicado: (2023)

Electric power substations engineering
por: McDonald, John D
Publicado: (2003)

Electrical substation at Laboratory II
Publicado: (1975)

Electrical substation at Laboratory II
Publicado: (1975)

Electric power substations engineering
por: McDonald, John D
Publicado: (2012)

Wireless communications for power substations
por: Agba, Basile L, et al.
Publicado: (2018)

Characterization of a PIP Binding Site in the N-Terminal Domain of V-ATPase a4 and Its Role in Plasma Membrane Association
por: Chu, Anh, et al.
Publicado: (2023)

Pip shape echoes grapevine domestication history
por: Bonhomme, Vincent, et al.
Publicado: (2021)

Substation automation systems: design and implementation
por: Padilla, Evelio
Publicado: (2015)

Security Baseline for Substation Automation Systems
por: Horalek, Josef, et al.
Publicado: (2023)

Mutagenesis of the Phosphatidylinositol 4,5-Bisphosphate (Pip(2)) Binding Site in the Nh(2)-Terminal Domain of Ezrin Correlates with Its Altered Cellular Distribution
por: Barret, Cécile, et al.
Publicado: (2000)

The microbiome in PTEN hamartoma tumor syndrome
por: Byrd, Victoria, et al.
Publicado: (2017)

Mutual inhibition between PTEN and PIP3 generates bistability for polarity in motile cells
por: Matsuoka, Satomi, et al.
Publicado: (2018)

Gastrointestinal polyposis and PTEN mutations: an under-acknowledged diagnostic criterion
por: Heald, Brandie, et al.
Publicado: (2010)

Smyd2 conformational changes in response to p53 binding: role of the C‐terminal domain
por: Chandramouli, Balasubramanian, et al.
Publicado: (2019)

Cowden syndrome-associated germline SDHD variants alter PTEN nuclear translocation through SRC-induced PTEN oxidation
por: Yu, Wanfeng, et al.
Publicado: (2015)

Conformational rearrangements in the second voltage sensor domain switch PIP(2)- and voltage-gating modes in two-pore channels
por: Shimomura, Takushi, et al.
Publicado: (2023)

Identification of the Conformational transition pathway in PIP(2) Opening Kir Channels
por: Li, Junwei, et al.
Publicado: (2015)

Erection of the 220 kV substation at CERN
por: CERN PhotoLab
Publicado: (1964)

The 18kV switchboard in the electricity substation
Publicado: (1974)

Germline TTN variants are enriched in PTEN-wildtype Bannayan–Riley–Ruvalcaba syndrome
por: Yehia, Lamis, et al.
Publicado: (2017)

ATP competes with PIP(2) for binding to gelsolin
por: Szatmári, Dávid, et al.
Publicado: (2018)

Role of BRCA2 DNA-binding and C-terminal domain in its mobility and conformation in DNA repair
por: Paul, Maarten W, et al.
Publicado: (2021)

Patient-derived mutations within the N-terminal domains of p85α impact PTEN or Rab5 binding and regulation
por: Mellor, Paul, et al.
Publicado: (2018)

Denial-of-Service Attack on IEC 61850-Based Substation Automation System: A Crucial Cyber Threat towards Smart Substation Pathways
por: Ashraf, Suleman, et al.
Publicado: (2021)

N-terminal transmembrane domain of SUR1 controls gating of Kir6.2 by modulating channel sensitivity to PIP(2)
por: Pratt, Emily B., et al.
Publicado: (2011)

Characterization of cryptic splicing in germline PTEN intronic variants in Cowden syndrome
por: Chen, Hannah Jinlian, et al.
Publicado: (2017)

The first of the LHCb experiment's muon substations is installed in the cavern
por: Schmidt, B
Publicado: (2007)

Major Refit for CERN's 400 kV Substation
Publicado: (2001)

BE 400/18 kV Substation Renovation Project
por: Vairo, Antonio, et al.
Publicado: (2001)

Proposal for the award of a contract for the contruction of an electrical substation
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_gakjtg7gqudtg764bpbbu7oagc