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Respuesta inmunitaria innata pulmonar en la infección por Sars-Cov-2
INTRODUCTION: The emerging infection caused by the new SARS-CoV-2 coronavirus has become a real challenge for the scientific community. Currently, there is little knowledge about the pathogenesis of COVID-19 and in recent times the participation of the host's own immune response in the progress...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Universidad Nacional de Córdoba
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004301/ https://www.ncbi.nlm.nih.gov/pubmed/35312259 http://dx.doi.org/10.31053/1853.0605.v79.n1.30642 |
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author | Bottino, Emanuel Alberto Ponce, Andrés |
author_facet | Bottino, Emanuel Alberto Ponce, Andrés |
author_sort | Bottino, Emanuel |
collection | PubMed |
description | INTRODUCTION: The emerging infection caused by the new SARS-CoV-2 coronavirus has become a real challenge for the scientific community. Currently, there is little knowledge about the pathogenesis of COVID-19 and in recent times the participation of the host's own immune response in the progression of the disease has been proposed. Innate pulmonary immunity is the first barrier against different toxins, which can cause tissue damage, with the consequent alteration of respiratory function. However, a loss in the regulation of these inflammatory mechanisms can cause a disruption in the homeostasis of the affected tissue. OBJECTIVE: To evaluate the role of the pulmonary innate immune response in the pathogenesis of COVID-19. MATERIALS AND METHODS: A systematic review of studies published in scientific search engines was carried out: PubMed, Google Scholar, Science Direct. The following keywords were used: "COVID-19"; "Acute Respiratory Distress Syndrome"; "SARS-CoV-2"; "Innate pulmonary immunity"; "Innate immune response". RESULTS: A global alteration of the pulmonary innate immune response was found in SARS-CoV-2 infection, which would have relevance in the pathogenesis of COVID-19. CONCLUSION: The global involvement of the innate immune response and consequently of lung tissue homeostasis, in SARS-CoV-2 infection, requires the design of new therapeutic strategies aimed at modulating the altered pro-inflammatory mechanisms in COVID-19. |
format | Online Article Text |
id | pubmed-9004301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Universidad Nacional de Córdoba |
record_format | MEDLINE/PubMed |
spelling | pubmed-90043012022-04-15 Respuesta inmunitaria innata pulmonar en la infección por Sars-Cov-2 Bottino, Emanuel Alberto Ponce, Andrés Rev Fac Cien Med Univ Nac Cordoba Revisiones De Literatura INTRODUCTION: The emerging infection caused by the new SARS-CoV-2 coronavirus has become a real challenge for the scientific community. Currently, there is little knowledge about the pathogenesis of COVID-19 and in recent times the participation of the host's own immune response in the progression of the disease has been proposed. Innate pulmonary immunity is the first barrier against different toxins, which can cause tissue damage, with the consequent alteration of respiratory function. However, a loss in the regulation of these inflammatory mechanisms can cause a disruption in the homeostasis of the affected tissue. OBJECTIVE: To evaluate the role of the pulmonary innate immune response in the pathogenesis of COVID-19. MATERIALS AND METHODS: A systematic review of studies published in scientific search engines was carried out: PubMed, Google Scholar, Science Direct. The following keywords were used: "COVID-19"; "Acute Respiratory Distress Syndrome"; "SARS-CoV-2"; "Innate pulmonary immunity"; "Innate immune response". RESULTS: A global alteration of the pulmonary innate immune response was found in SARS-CoV-2 infection, which would have relevance in the pathogenesis of COVID-19. CONCLUSION: The global involvement of the innate immune response and consequently of lung tissue homeostasis, in SARS-CoV-2 infection, requires the design of new therapeutic strategies aimed at modulating the altered pro-inflammatory mechanisms in COVID-19. Universidad Nacional de Córdoba 2022-03-07 /pmc/articles/PMC9004301/ /pubmed/35312259 http://dx.doi.org/10.31053/1853.0605.v79.n1.30642 Text en https://creativecommons.org/licenses/by-nc/4.0/Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial 4.0. |
spellingShingle | Revisiones De Literatura Bottino, Emanuel Alberto Ponce, Andrés Respuesta inmunitaria innata pulmonar en la infección por Sars-Cov-2 |
title | Respuesta inmunitaria innata pulmonar en la infección por Sars-Cov-2 |
title_full | Respuesta inmunitaria innata pulmonar en la infección por Sars-Cov-2 |
title_fullStr | Respuesta inmunitaria innata pulmonar en la infección por Sars-Cov-2 |
title_full_unstemmed | Respuesta inmunitaria innata pulmonar en la infección por Sars-Cov-2 |
title_short | Respuesta inmunitaria innata pulmonar en la infección por Sars-Cov-2 |
title_sort | respuesta inmunitaria innata pulmonar en la infección por sars-cov-2 |
topic | Revisiones De Literatura |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004301/ https://www.ncbi.nlm.nih.gov/pubmed/35312259 http://dx.doi.org/10.31053/1853.0605.v79.n1.30642 |
work_keys_str_mv | AT bottinoemanuel respuestainmunitariainnatapulmonarenlainfeccionporsarscov2 AT albertoponceandres respuestainmunitariainnatapulmonarenlainfeccionporsarscov2 |