Absolute configuration determination of pharmaceutical crystalline powders by MicroED via chiral salt formation

Microcrystal electron diffraction (MicroED) has established its complementary role alongside X-ray diffraction in crystal structure elucidation. Unfortunately, kinematical refinement of MicroED data lacks the differentiation power to assign the absolute structure solely based on the measured intensi...

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Detalles Bibliográficos
Autores principales: Wang, Bo, Bruhn, Jessica F., Weldeab, Asmerom, Wilson, Timothy S., McGilvray, Philip T., Mashore, Michael, Song, Qiong, Scapin, Giovanna, Lin, Yiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004345/
https://www.ncbi.nlm.nih.gov/pubmed/35293405
http://dx.doi.org/10.1039/d2cc00221c
Descripción
Sumario:Microcrystal electron diffraction (MicroED) has established its complementary role alongside X-ray diffraction in crystal structure elucidation. Unfortunately, kinematical refinement of MicroED data lacks the differentiation power to assign the absolute structure solely based on the measured intensities. Here we report a method for absolute configuration determination via MicroED by employing salt formation with chiral counterions.

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