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High replication stress and limited Rad51-mediated DNA repair capacity, but not oxidative stress, underlie oligodendrocyte precursor cell radiosensitivity

Cranial irradiation is part of the standard of care for treating pediatric brain tumors. However, ionizing radiation can trigger serious long-term neurologic sequelae, including oligodendrocyte and brain white matter loss enabling neurocognitive decline in children surviving brain cancer. Oxidative...

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Detalles Bibliográficos
Autores principales:	Berger, N Daniel, Brownlee, Peter M, Chen, Myra J, Morrison, Hali, Osz, Katalin, Ploquin, Nicolas P, Chan, Jennifer A, Goodarzi, Aaron A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	DNA Damage Sensing and Repair
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004414/ https://www.ncbi.nlm.nih.gov/pubmed/35425901 http://dx.doi.org/10.1093/narcan/zcac012

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