Photorepair of Either CPD or 6-4PP DNA Lesions in Basal Keratinocytes Attenuates Ultraviolet-Induced Skin Effects in Nucleotide Excision Repair Deficient Mice

Ultraviolet (UV) radiation is one of the most genotoxic, universal agents present in the environment. UVB (280-315 nm) radiation directly damages DNA, producing cyclobutane pyrimidine dimers (CPDs) and pyrimidine 6-4 pyrimidone photoproducts (6-4PPs). These photolesions interfere with essential cell...

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Detalles Bibliográficos
Autores principales: Kajitani, Gustavo S., Quayle, Carolina, Garcia, Camila C. M., Fotoran, Wesley L., dos Santos, Juliana F. R., van der Horst, Gijsbertus T. J., Hoeijmakers, Jan H. J., Menck, Carlos F. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004445/
https://www.ncbi.nlm.nih.gov/pubmed/35422806
http://dx.doi.org/10.3389/fimmu.2022.800606

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