Disrupting the MYC-TFEB Circuit Impairs Amino Acid Homeostasis and Provokes Metabolic Anergy

MYC family oncoproteins are regulators of metabolic reprogramming that sustains cancer cell anabolism. Normal cells adapt to nutrient-limiting conditions by activating autophagy, which is required for amino acid (AA) homeostasis. Here we report that the autophagy pathway is suppressed by Myc in norm...

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Detalles Bibliográficos
Autores principales: Fernandez, Mario R., Schaub, Franz X., Yang, Chunying, Li, Weimin, Yun, Seongseok, Schaub, Stephanie K., Dorsey, Frank C., Liu, Min, Steeves, Meredith A., Ballabio, Andrea, Tzankov, Alexandar, Chen, Zhihua, Koomen, John M., Berglund, Anders E., Cleveland, John L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Metabolism and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004540/
https://www.ncbi.nlm.nih.gov/pubmed/35149590
http://dx.doi.org/10.1158/0008-5472.CAN-21-1168

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