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Ovarian reserve parameters and IVF outcomes in 510 women with poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP)

The aim of the current study was to characterize ovarian reserve parameters and IVF outcomes in women with a history of poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP). Reproductive age women (N=510; age range 30-45yo) diagnosed with POR based...

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Autores principales: Cakiroglu, Yigit, Yuceturk, Aysen, Karaosmanoglu, Ozge, Kopuk, Sule Yildirim, Korun, Zeynep Ece Utkan, Herlihy, Nola, Scott, Richard T., Tiras, Bulent, Seli, Emre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004561/
https://www.ncbi.nlm.nih.gov/pubmed/35320118
http://dx.doi.org/10.18632/aging.203972
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author Cakiroglu, Yigit
Yuceturk, Aysen
Karaosmanoglu, Ozge
Kopuk, Sule Yildirim
Korun, Zeynep Ece Utkan
Herlihy, Nola
Scott, Richard T.
Tiras, Bulent
Seli, Emre
author_facet Cakiroglu, Yigit
Yuceturk, Aysen
Karaosmanoglu, Ozge
Kopuk, Sule Yildirim
Korun, Zeynep Ece Utkan
Herlihy, Nola
Scott, Richard T.
Tiras, Bulent
Seli, Emre
author_sort Cakiroglu, Yigit
collection PubMed
description The aim of the current study was to characterize ovarian reserve parameters and IVF outcomes in women with a history of poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP). Reproductive age women (N=510; age range 30-45yo) diagnosed with POR based on Poseidon criteria were included in the study. PRP treatment resulted in higher AFC, higher serum AMH, lower serum FSH, and a higher number of mature oocytes and cleavage and blastocyst stage embryos. After PRP injection, 22 women (4.3%) conceived spontaneously, 14 (2.7%) were lost to follow up, and 474 (92.9%) attempted IVF. Among women who attempted IVF, 312 (65.8%) generated embryos and underwent embryo transfer, 83 (17.5%) achieved a pregnancy, and 54 (11.4%) achieved sustained implantation/live birth (SI/LB). In total, of the 510 women with POR and mean age of 40.3, PRP resulted in improvement of ovarian reserve parameters, a pregnancy rate of 20.5% and SI/LB rate of 12.9%. Our findings suggest that PRP treatment may be considered in women with POR. For wider clinical application, its clinical efficacy will need to be demonstrated in prospective randomized clinical trials.
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spelling pubmed-90045612022-04-13 Ovarian reserve parameters and IVF outcomes in 510 women with poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP) Cakiroglu, Yigit Yuceturk, Aysen Karaosmanoglu, Ozge Kopuk, Sule Yildirim Korun, Zeynep Ece Utkan Herlihy, Nola Scott, Richard T. Tiras, Bulent Seli, Emre Aging (Albany NY) Research Paper The aim of the current study was to characterize ovarian reserve parameters and IVF outcomes in women with a history of poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP). Reproductive age women (N=510; age range 30-45yo) diagnosed with POR based on Poseidon criteria were included in the study. PRP treatment resulted in higher AFC, higher serum AMH, lower serum FSH, and a higher number of mature oocytes and cleavage and blastocyst stage embryos. After PRP injection, 22 women (4.3%) conceived spontaneously, 14 (2.7%) were lost to follow up, and 474 (92.9%) attempted IVF. Among women who attempted IVF, 312 (65.8%) generated embryos and underwent embryo transfer, 83 (17.5%) achieved a pregnancy, and 54 (11.4%) achieved sustained implantation/live birth (SI/LB). In total, of the 510 women with POR and mean age of 40.3, PRP resulted in improvement of ovarian reserve parameters, a pregnancy rate of 20.5% and SI/LB rate of 12.9%. Our findings suggest that PRP treatment may be considered in women with POR. For wider clinical application, its clinical efficacy will need to be demonstrated in prospective randomized clinical trials. Impact Journals 2022-03-22 /pmc/articles/PMC9004561/ /pubmed/35320118 http://dx.doi.org/10.18632/aging.203972 Text en Copyright: © 2022 Cakiroglu et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Cakiroglu, Yigit
Yuceturk, Aysen
Karaosmanoglu, Ozge
Kopuk, Sule Yildirim
Korun, Zeynep Ece Utkan
Herlihy, Nola
Scott, Richard T.
Tiras, Bulent
Seli, Emre
Ovarian reserve parameters and IVF outcomes in 510 women with poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP)
title Ovarian reserve parameters and IVF outcomes in 510 women with poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP)
title_full Ovarian reserve parameters and IVF outcomes in 510 women with poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP)
title_fullStr Ovarian reserve parameters and IVF outcomes in 510 women with poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP)
title_full_unstemmed Ovarian reserve parameters and IVF outcomes in 510 women with poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP)
title_short Ovarian reserve parameters and IVF outcomes in 510 women with poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP)
title_sort ovarian reserve parameters and ivf outcomes in 510 women with poor ovarian response (por) treated with intraovarian injection of autologous platelet rich plasma (prp)
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004561/
https://www.ncbi.nlm.nih.gov/pubmed/35320118
http://dx.doi.org/10.18632/aging.203972
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