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Regulation of mTOR complexes in long-lived growth hormone receptor knockout and Snell dwarf mice

Downregulation of mTOR (mechanistic target of rapamycin) can extend lifespan in multiple species, including mice. Growth hormone receptor knockout mice (GHRKO) and Snell dwarf mice have 40% or greater lifespan increase, and have lower mTORC1 function, which might reflect alteration in mTORC1 compone...

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Detalles Bibliográficos
Autores principales:	Shi, Xiaofang, Endicott, S. Joseph, Miller, Richard A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2022
Materias:	Priority Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004569/ https://www.ncbi.nlm.nih.gov/pubmed/35305083 http://dx.doi.org/10.18632/aging.203959

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