Tumor Suppressor Par-4 Regulates Complement Factor C3 and Obesity

Prostate apoptosis response-4 (Par-4) is a tumor suppressor that induces apoptosis in cancer cells. However, the physiological function of Par-4 remains unknown. Here we show that conventional Par-4 knockout (Par-4(-/-)) mice and adipocyte-specific Par-4 knockout (AKO) mice, but not hepatocyte-speci...

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Detalles Bibliográficos
Autores principales: Araujo, Nathalia, Sledziona, James, Noothi, Sunil K., Burikhanov, Ravshan, Hebbar, Nikhil, Ganguly, Saptadwipa, Shrestha-Bhattarai, Tripti, Zhu, Beibei, Katz, Wendy S., Zhang, Yi, Taylor, Barry S., Liu, Jinze, Chen, Li, Weiss, Heidi L., He, Daheng, Wang, Chi, Morris, Andrew J., Cassis, Lisa A., Nikolova-Karakashian, Mariana, Nagareddy, Prabhakar R., Melander, Olle, Evers, B. Mark, Kern, Philip A., Rangnekar, Vivek M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004617/
https://www.ncbi.nlm.nih.gov/pubmed/35425699
http://dx.doi.org/10.3389/fonc.2022.860446

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