Cargando…

Double drugging of prolyl-tRNA synthetase provides a new paradigm for anti-infective drug development

Toxoplasmosis is caused by Toxoplasma gondii and in immunocompromised patients it may lead to seizures, encephalitis or death. The conserved enzyme prolyl-tRNA synthetase (PRS) is a validated druggable target in Toxoplasma gondii but the traditional ‘single target–single drug’ approach has its cavea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Manickam, Yogavel, Malhotra, Nipun, Mishra, Siddhartha, Babbar, Palak, Dusane, Abhishek, Laleu, Benoît, Bellini, Valeria, Hakimi, Mohamed-Ali, Bougdour, Alexandre, Sharma, Amit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004777/ https://www.ncbi.nlm.nih.gov/pubmed/35333915 http://dx.doi.org/10.1371/journal.ppat.1010363

Ejemplares similares

Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis
por: Yogavel, Manickam, et al.
Publicado: (2023)

Protein Translation Enzyme lysyl-tRNA Synthetase Presents a New Target for Drug Development against Causative Agents of Loiasis and Schistosomiasis
por: Sharma, Arvind, et al.
Publicado: (2016)

Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines
por: Sharma, Manmohan, et al.
Publicado: (2021)

Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase
por: Hewitt, Stephen Nakazawa, et al.
Publicado: (2016)

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase
por: Keller, Tracy L., et al.
Publicado: (2012)

Evolution of acceptor stem tRNA recognition by class II prolyl-tRNA synthetase
por: An, Songon, et al.
Publicado: (2008)

An Appended Domain Results in an Unusual Architecture for Malaria Parasite Tryptophanyl-tRNA Synthetase
por: Khan, Sameena, et al.
Publicado: (2013)

Prolyl-tRNA synthetase as a novel therapeutic target in multiple myeloma
por: Kurata, Keiji, et al.
Publicado: (2023)

Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance
por: Tye, Mark A., et al.
Publicado: (2022)

Correction: Prolyl-tRNA synthetase as a novel therapeutic target in multiple myeloma
por: Kurata, Keiji, et al.
Publicado: (2023)

Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Plasmodium Cytoplasmic Prolyl-tRNA Synthetase Inhibitors
por: Okaniwa, Masanori, et al.
Publicado: (2021)

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis
por: Baragaña, Beatriz, et al.
Publicado: (2019)

Phosphocode-dependent glutamyl-prolyl-tRNA synthetase 1 signaling in immunity, metabolism, and disease
por: Lee, Eun-Young, et al.
Publicado: (2023)

Control of fibrosis with enhanced safety via asymmetric inhibition of prolyl‐tRNA synthetase 1
por: Yoon, Ina, et al.
Publicado: (2023)

Strictly Conserved Lysine of Prolyl-tRNA Synthetase Editing Domain Facilitates Binding and Positioning of Misacylated tRNA(Pro)
por: Bartholow, Thomas G., et al.
Publicado: (2014)

Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase
por: Palencia, Andrés, et al.
Publicado: (2016)

The zinc-binding domain of mammalian prolyl-tRNA synthetase is indispensable for catalytic activity and organism viability
por: Vasu, Kommireddy, et al.
Publicado: (2021)

Glutamyl-prolyl-tRNA synthetase 1 coordinates early endosomal anti-inflammatory AKT signaling
por: Lee, Eun-Young, et al.
Publicado: (2022)

Whole exome sequencing reveals mutations in NARS2 and PARS2, encoding the mitochondrial asparaginyl-tRNA synthetase and prolyl-tRNA synthetase, in patients with Alpers syndrome
por: Sofou, Kalliopi, et al.
Publicado: (2015)

Aminoacyl-tRNA synthetases as drug targets in eukaryotic parasites()
por: Pham, James S., et al.
Publicado: (2013)

Origin and Evolution of Glutamyl-prolyl tRNA Synthetase WHEP Domains Reveal Evolutionary Relationships within Holozoa
por: Ray, Partho Sarothi, et al.
Publicado: (2014)

Discovery and pharmacological characterization of a new class of prolyl-tRNA synthetase inhibitor for anti-fibrosis therapy
por: Shibata, Akira, et al.
Publicado: (2017)

Cardiomyocyte-specific Loss of Glutamyl-prolyl-tRNA Synthetase Leads to Disturbed Protein Homeostasis and Dilated Cardiomyopathy
por: Wu, Jiangbin, et al.
Publicado: (2023)

Adenosine-Mimicking Derivatives of 3-Aminopyrazine-2-Carboxamide: Towards Inhibitors of Prolyl-tRNA Synthetase with Antimycobacterial Activity
por: Pallabothula, Vinod Sukanth Kumar, et al.
Publicado: (2022)

Safety, tolerability, pharmacokinetic/pharmacodynamic characteristics of bersiporocin, a novel prolyl‐tRNA synthetase inhibitor, in healthy subjects
por: Park, Min Young, et al.
Publicado: (2023)

Aminoacyl-tRNA Synthetases as Valuable Targets for Antimicrobial Drug Discovery
por: Pang, Luping, et al.
Publicado: (2021)

Aminoacyl tRNA synthetases as potential drug targets of the Panthera pathogen Babesia
por: Chhibber-Goel, Jyoti, et al.
Publicado: (2019)

Exploration of aminoacyl-tRNA synthetases from eukaryotic parasites for drug development
por: Gill, Jasmita, et al.
Publicado: (2022)

Bacterial Aspartyl-tRNA Synthetase Has Glutamyl-tRNA Synthetase Activity
por: Rathnayake, Udumbara M., et al.
Publicado: (2019)

Aminoacyl-tRNA synthetases of the multi-tRNA synthetase complex and their role in tumorigenesis
por: Khan, Krishnendu, et al.
Publicado: (2022)

Glutamyl-Prolyl-tRNA Synthetase Regulates Epithelial Expression of Mesenchymal Markers and Extracellular Matrix Proteins: Implications for Idiopathic Pulmonary Fibrosis
por: Song, Dae-Geun, et al.
Publicado: (2018)

Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies
por: Pang, Luping, et al.
Publicado: (2021)

Identification of glutamyl-prolyl-tRNA synthetase as a new therapeutic target in hepatocellular carcinoma via a novel bioinformatic approach
por: Shu, Jinyong, et al.
Publicado: (2023)

Aminoacyl-tRNA synthetases
por: Rubio Gomez, Miguel Angel, et al.
Publicado: (2020)

Expanding a tyrosyl-tRNA synthetase assay to other aminoacyl-tRNA synthetases
por: Richardson, Charles J., et al.
Publicado: (2015)

Recent advances in the biology and drug targeting of malaria parasite aminoacyl-tRNA synthetases
por: Khan, Sameena
Publicado: (2016)

Aminoacyl tRNA synthetases as malarial drug targets: a comparative bioinformatics study
por: Nyamai, Dorothy Wavinya, et al.
Publicado: (2019)

Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs
por: Green, Simon R., et al.
Publicado: (2022)

Aminoacyl-tRNA Synthetases: On Anti-Synthetase Syndrome and Beyond
por: Galindo-Feria, Angeles S., et al.
Publicado: (2022)

Structural basis for the dynamics of human methionyl-tRNA synthetase in multi-tRNA synthetase complexes
por: Kim, Dong Kyu, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9r6uf0e2jv3910p0d00fq7rrlq