Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function

Loss-of-function mutations in the depalmitoylating enzyme palmitoyl protein thioesterase 1 (PPT1) cause neuronal ceroid lipofuscinosis (NCL), a devastating neurodegenerative disease. The substrates of PPT1 are largely undescribed, posing a limitation on molecular dissection of disease mechanisms and...

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Detalles Bibliográficos
Autores principales: Gorenberg, Erica L., Massaro Tieze, Sofia, Yücel, Betül, Zhao, Helen R., Chou, Vicky, Wirak, Gregory S., Tomita, Susumu, Lam, TuKiet T., Chandra, Sreeganga S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Methods and Resources
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004782/
https://www.ncbi.nlm.nih.gov/pubmed/35358180
http://dx.doi.org/10.1371/journal.pbio.3001590

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