Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs

The recognition that individual GPCRs can activate multiple signaling pathways has raised the possibility of developing drugs selectively targeting therapeutically relevant ones. This requires tools to determine which G proteins and βarrestins are activated by a given receptor. Here, we present a se...

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Detalles Bibliográficos
Autores principales: Avet, Charlotte, Mancini, Arturo, Breton, Billy, Le Gouill, Christian, Hauser, Alexander S, Normand, Claire, Kobayashi, Hiroyuki, Gross, Florence, Hogue, Mireille, Lukasheva, Viktoriya, St-Onge, Stéphane, Carrier, Marilyn, Héroux, Madeleine, Morissette, Sandra, Fauman, Eric B, Fortin, Jean-Philippe, Schann, Stephan, Leroy, Xavier, Gloriam, David E, Bouvier, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005190/
https://www.ncbi.nlm.nih.gov/pubmed/35302493
http://dx.doi.org/10.7554/eLife.74101

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