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Treatment of in-transit Merkel cell carcinoma by isolated limb infusion with cytotoxic drugs
Merkel cell carcinoma of the skin is a rare but aggressive malignancy, which predominantly affects older adults with fair skin. Isolated limb infusion (ILI) using melphalan and actinomycin D was first developed as a minimally invasive treatment option to treat unresectable metastatic melanoma confin...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005209/ https://www.ncbi.nlm.nih.gov/pubmed/35422991 http://dx.doi.org/10.1093/jscr/rjac172 |
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author | Hindmarch, Jake J Coker, David J Waugh, Richard Kam, Peter C A Thompson, John F Saw, Robyn P M |
author_facet | Hindmarch, Jake J Coker, David J Waugh, Richard Kam, Peter C A Thompson, John F Saw, Robyn P M |
author_sort | Hindmarch, Jake J |
collection | PubMed |
description | Merkel cell carcinoma of the skin is a rare but aggressive malignancy, which predominantly affects older adults with fair skin. Isolated limb infusion (ILI) using melphalan and actinomycin D was first developed as a minimally invasive treatment option to treat unresectable metastatic melanoma confined to the limb. We report on a 62-year-old male with in-transit metastases (ITMs) treated with ILI to highlight the ongoing role this treatment has when all other therapies have been exhausted. At presentation, the patient had widespread ITMs in the right leg. Positron emission tomography scan demonstrated recurrent disease in the thigh and pelvis, and it was decided to treat the patient with ILI. The patient progressed well in the immediate post-operative period. The patient was able to mobilize from Day 6 post-ILI and was discharged on Day 10. There was an immediate clinical response seen in the lesions, with necrosis developing in the larger lesions. |
format | Online Article Text |
id | pubmed-9005209 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-90052092022-04-13 Treatment of in-transit Merkel cell carcinoma by isolated limb infusion with cytotoxic drugs Hindmarch, Jake J Coker, David J Waugh, Richard Kam, Peter C A Thompson, John F Saw, Robyn P M J Surg Case Rep Case Report Merkel cell carcinoma of the skin is a rare but aggressive malignancy, which predominantly affects older adults with fair skin. Isolated limb infusion (ILI) using melphalan and actinomycin D was first developed as a minimally invasive treatment option to treat unresectable metastatic melanoma confined to the limb. We report on a 62-year-old male with in-transit metastases (ITMs) treated with ILI to highlight the ongoing role this treatment has when all other therapies have been exhausted. At presentation, the patient had widespread ITMs in the right leg. Positron emission tomography scan demonstrated recurrent disease in the thigh and pelvis, and it was decided to treat the patient with ILI. The patient progressed well in the immediate post-operative period. The patient was able to mobilize from Day 6 post-ILI and was discharged on Day 10. There was an immediate clinical response seen in the lesions, with necrosis developing in the larger lesions. Oxford University Press 2022-04-12 /pmc/articles/PMC9005209/ /pubmed/35422991 http://dx.doi.org/10.1093/jscr/rjac172 Text en Published by Oxford University Press and JSCR Publishing Ltd. © The Author(s) 2022. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Hindmarch, Jake J Coker, David J Waugh, Richard Kam, Peter C A Thompson, John F Saw, Robyn P M Treatment of in-transit Merkel cell carcinoma by isolated limb infusion with cytotoxic drugs |
title | Treatment of in-transit Merkel cell carcinoma by isolated limb infusion with cytotoxic drugs |
title_full | Treatment of in-transit Merkel cell carcinoma by isolated limb infusion with cytotoxic drugs |
title_fullStr | Treatment of in-transit Merkel cell carcinoma by isolated limb infusion with cytotoxic drugs |
title_full_unstemmed | Treatment of in-transit Merkel cell carcinoma by isolated limb infusion with cytotoxic drugs |
title_short | Treatment of in-transit Merkel cell carcinoma by isolated limb infusion with cytotoxic drugs |
title_sort | treatment of in-transit merkel cell carcinoma by isolated limb infusion with cytotoxic drugs |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005209/ https://www.ncbi.nlm.nih.gov/pubmed/35422991 http://dx.doi.org/10.1093/jscr/rjac172 |
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