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Polyethyleneimine (PEI) as a Polymer-Based Co-Delivery System for Breast Cancer Therapy

Cancer has become one of the leading causes of morbidity and mortality worldwide. This disease is classified broadly by tissue, organ, and system; different cancer types and subtypes require different treatments. Drug bioavailability, selectivity, and high dosage, as well as extended treatment, are...

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Autores principales: Fahira, Alistia Ilmiah, Amalia, Riezki, Barliana, Melisa Intan, Gatera, Vesara Ardhe, Abdulah, Rizky
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005234/
https://www.ncbi.nlm.nih.gov/pubmed/35422657
http://dx.doi.org/10.2147/BCTT.S350403
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author Fahira, Alistia Ilmiah
Amalia, Riezki
Barliana, Melisa Intan
Gatera, Vesara Ardhe
Abdulah, Rizky
author_facet Fahira, Alistia Ilmiah
Amalia, Riezki
Barliana, Melisa Intan
Gatera, Vesara Ardhe
Abdulah, Rizky
author_sort Fahira, Alistia Ilmiah
collection PubMed
description Cancer has become one of the leading causes of morbidity and mortality worldwide. This disease is classified broadly by tissue, organ, and system; different cancer types and subtypes require different treatments. Drug bioavailability, selectivity, and high dosage, as well as extended treatment, are significantly associated with the development of resistance – a complex problem in cancer therapy. It is expected that the combination of anticancer drugs and drug delivery systems, using polymers to increase the access of such agents to their site of action, will improve the efficacy of therapy. Polyethyleneimine (PEI) is a polymer used as a co-delivery system for anticancer drugs and gene therapy. PEI is also useful for other purposes, such as transfection and bio-adsorbent agents. In co-delivery, PEI can promote drug internalization. However, PEI with a high molecular weight is linked to higher cytotoxicity, thus requiring further evaluation of clinical safety. This review focuses on the utilization of PEI as a co-delivery system for anticancer therapy, as well as its potential to overcome resistance, particularly in the treatment of specific subtypes (eg, breast cancer). In conclusion, PEI has promising applications and is improvable for the development of anticancer drugs.
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spelling pubmed-90052342022-04-13 Polyethyleneimine (PEI) as a Polymer-Based Co-Delivery System for Breast Cancer Therapy Fahira, Alistia Ilmiah Amalia, Riezki Barliana, Melisa Intan Gatera, Vesara Ardhe Abdulah, Rizky Breast Cancer (Dove Med Press) Review Cancer has become one of the leading causes of morbidity and mortality worldwide. This disease is classified broadly by tissue, organ, and system; different cancer types and subtypes require different treatments. Drug bioavailability, selectivity, and high dosage, as well as extended treatment, are significantly associated with the development of resistance – a complex problem in cancer therapy. It is expected that the combination of anticancer drugs and drug delivery systems, using polymers to increase the access of such agents to their site of action, will improve the efficacy of therapy. Polyethyleneimine (PEI) is a polymer used as a co-delivery system for anticancer drugs and gene therapy. PEI is also useful for other purposes, such as transfection and bio-adsorbent agents. In co-delivery, PEI can promote drug internalization. However, PEI with a high molecular weight is linked to higher cytotoxicity, thus requiring further evaluation of clinical safety. This review focuses on the utilization of PEI as a co-delivery system for anticancer therapy, as well as its potential to overcome resistance, particularly in the treatment of specific subtypes (eg, breast cancer). In conclusion, PEI has promising applications and is improvable for the development of anticancer drugs. Dove 2022-04-08 /pmc/articles/PMC9005234/ /pubmed/35422657 http://dx.doi.org/10.2147/BCTT.S350403 Text en © 2022 Fahira et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Fahira, Alistia Ilmiah
Amalia, Riezki
Barliana, Melisa Intan
Gatera, Vesara Ardhe
Abdulah, Rizky
Polyethyleneimine (PEI) as a Polymer-Based Co-Delivery System for Breast Cancer Therapy
title Polyethyleneimine (PEI) as a Polymer-Based Co-Delivery System for Breast Cancer Therapy
title_full Polyethyleneimine (PEI) as a Polymer-Based Co-Delivery System for Breast Cancer Therapy
title_fullStr Polyethyleneimine (PEI) as a Polymer-Based Co-Delivery System for Breast Cancer Therapy
title_full_unstemmed Polyethyleneimine (PEI) as a Polymer-Based Co-Delivery System for Breast Cancer Therapy
title_short Polyethyleneimine (PEI) as a Polymer-Based Co-Delivery System for Breast Cancer Therapy
title_sort polyethyleneimine (pei) as a polymer-based co-delivery system for breast cancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005234/
https://www.ncbi.nlm.nih.gov/pubmed/35422657
http://dx.doi.org/10.2147/BCTT.S350403
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