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Metabolic Remodeling Impacts the Epigenetic Landscape of Dental Mesenchymal Stem Cells

Epigenetic regulation can dynamically adjust the gene expression program of cell fate decision according to the cellular microenvironment. Emerging studies have shown that metabolic activities provide fundamental components for epigenetic modifications and these metabolic-sensitive epigenetic events...

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Detalles Bibliográficos
Autores principales: Luo, Haiyun, Zhou, Yachuan, Liu, Wenjing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005295/
https://www.ncbi.nlm.nih.gov/pubmed/35422867
http://dx.doi.org/10.1155/2022/3490433
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author Luo, Haiyun
Zhou, Yachuan
Liu, Wenjing
author_facet Luo, Haiyun
Zhou, Yachuan
Liu, Wenjing
author_sort Luo, Haiyun
collection PubMed
description Epigenetic regulation can dynamically adjust the gene expression program of cell fate decision according to the cellular microenvironment. Emerging studies have shown that metabolic activities provide fundamental components for epigenetic modifications and these metabolic-sensitive epigenetic events dramatically impact the cellular function of stem cells. Dental mesenchymal stem cells are promising adult stem cell resource for in situ injury repair and tissue engineering. In this review, we discuss the impact of metabolic fluctuations on epigenetic modifications in the oral and maxillofacial regions. The principles of the metabolic link to epigenetic modifications and the interaction between metabolite substrates and canonical epigenetic events in dental mesenchymal stem cells are summarized. The coordination between metabolic pathways and epigenetic events plays an important role in cellular progresses including differentiation, inflammatory responses, and aging. The metabolic-epigenetic network is critical for expanding our current understanding of tissue homeostasis and cell fate decision and for guiding potential therapeutic approaches in dental regeneration and infectious diseases.
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spelling pubmed-90052952022-04-13 Metabolic Remodeling Impacts the Epigenetic Landscape of Dental Mesenchymal Stem Cells Luo, Haiyun Zhou, Yachuan Liu, Wenjing Stem Cells Int Review Article Epigenetic regulation can dynamically adjust the gene expression program of cell fate decision according to the cellular microenvironment. Emerging studies have shown that metabolic activities provide fundamental components for epigenetic modifications and these metabolic-sensitive epigenetic events dramatically impact the cellular function of stem cells. Dental mesenchymal stem cells are promising adult stem cell resource for in situ injury repair and tissue engineering. In this review, we discuss the impact of metabolic fluctuations on epigenetic modifications in the oral and maxillofacial regions. The principles of the metabolic link to epigenetic modifications and the interaction between metabolite substrates and canonical epigenetic events in dental mesenchymal stem cells are summarized. The coordination between metabolic pathways and epigenetic events plays an important role in cellular progresses including differentiation, inflammatory responses, and aging. The metabolic-epigenetic network is critical for expanding our current understanding of tissue homeostasis and cell fate decision and for guiding potential therapeutic approaches in dental regeneration and infectious diseases. Hindawi 2022-04-05 /pmc/articles/PMC9005295/ /pubmed/35422867 http://dx.doi.org/10.1155/2022/3490433 Text en Copyright © 2022 Haiyun Luo et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Luo, Haiyun
Zhou, Yachuan
Liu, Wenjing
Metabolic Remodeling Impacts the Epigenetic Landscape of Dental Mesenchymal Stem Cells
title Metabolic Remodeling Impacts the Epigenetic Landscape of Dental Mesenchymal Stem Cells
title_full Metabolic Remodeling Impacts the Epigenetic Landscape of Dental Mesenchymal Stem Cells
title_fullStr Metabolic Remodeling Impacts the Epigenetic Landscape of Dental Mesenchymal Stem Cells
title_full_unstemmed Metabolic Remodeling Impacts the Epigenetic Landscape of Dental Mesenchymal Stem Cells
title_short Metabolic Remodeling Impacts the Epigenetic Landscape of Dental Mesenchymal Stem Cells
title_sort metabolic remodeling impacts the epigenetic landscape of dental mesenchymal stem cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005295/
https://www.ncbi.nlm.nih.gov/pubmed/35422867
http://dx.doi.org/10.1155/2022/3490433
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