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Pangenome-based genome inference allows efficient and accurate genotyping across a wide spectrum of variant classes
Typical genotyping workflows map reads to a reference genome before identifying genetic variants. Generating such alignments introduces reference biases and comes with substantial computational burden. Furthermore, short-read lengths limit the ability to characterize repetitive genomic regions, whic...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group US
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005351/ https://www.ncbi.nlm.nih.gov/pubmed/35410384 http://dx.doi.org/10.1038/s41588-022-01043-w |