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Optimal Medical Therapy for Secondary Prevention of Acute Coronary Syndrome: A Retrospective Study from a Tertiary Hospital in Sudan

BACKGROUND: Five-medication regimen is recommended for patients after acute coronary syndrome (ACS) as a secondary prevention strategy at discharge to reduce recurrence and improve mortality. OBJECTIVE: This study aimed to assess prescribing of optimal medical therapy (OMT) as five-medication regime...

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Autores principales: Ahmed, Kannan O, Ahmed, Ashraf M, Wali, Mojahed B, Ali, Ali H, Azhari, Mustafa M, Babiker, Anas, Yousef, Bashir A, Muddather, Hiba F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005352/
https://www.ncbi.nlm.nih.gov/pubmed/35431548
http://dx.doi.org/10.2147/TCRM.S361129
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author Ahmed, Kannan O
Ahmed, Ashraf M
Wali, Mojahed B
Ali, Ali H
Azhari, Mustafa M
Babiker, Anas
Yousef, Bashir A
Muddather, Hiba F
author_facet Ahmed, Kannan O
Ahmed, Ashraf M
Wali, Mojahed B
Ali, Ali H
Azhari, Mustafa M
Babiker, Anas
Yousef, Bashir A
Muddather, Hiba F
author_sort Ahmed, Kannan O
collection PubMed
description BACKGROUND: Five-medication regimen is recommended for patients after acute coronary syndrome (ACS) as a secondary prevention strategy at discharge to reduce recurrence and improve mortality. OBJECTIVE: This study aimed to assess prescribing of optimal medical therapy (OMT) as five-medication regimens for secondary prevention at discharge after ACS in Sudan. METHODS: A retrospective cohort study was performed at a tertiary hospital located in Wad Medani, Sudan, in the period between January and December 2019. Data were collected from patients’ files. OMT was defined as a combination of five medications; aspirin and P2Y12 inhibitors, statins, beta-blockers (BBs), and angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin receptor blockers (ARBs) or if a valid contraindication was documented. RESULTS: Of the 619 patients throughout the study period, 591 were selected based on inclusion and exclusion criteria. The median age of patients was 60 years, and 58.9% of patients were male. Diabetes (44.5%) and hypertension (42%) were the most common risk factors. Most patients (58.4%) were diagnosed with ST-segment elevation myocardial infarction. About 99.7% of patients were on aspirin, 99.5% on statins, 97% on clopidogrel, 96.8% on dual antiplatelet therapy, 70.4% on BBs, and 57.9% on ACEIs/ARBs. OMT for secondary prevention was prescribed to 267 (45.2%) patients with ACS at discharge. CONCLUSION: Although prescriptions for all five guideline-recommended medications after ACS were suboptimal, the study showed a positive trend in prescribing most individual medications.
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spelling pubmed-90053522022-04-14 Optimal Medical Therapy for Secondary Prevention of Acute Coronary Syndrome: A Retrospective Study from a Tertiary Hospital in Sudan Ahmed, Kannan O Ahmed, Ashraf M Wali, Mojahed B Ali, Ali H Azhari, Mustafa M Babiker, Anas Yousef, Bashir A Muddather, Hiba F Ther Clin Risk Manag Original Research BACKGROUND: Five-medication regimen is recommended for patients after acute coronary syndrome (ACS) as a secondary prevention strategy at discharge to reduce recurrence and improve mortality. OBJECTIVE: This study aimed to assess prescribing of optimal medical therapy (OMT) as five-medication regimens for secondary prevention at discharge after ACS in Sudan. METHODS: A retrospective cohort study was performed at a tertiary hospital located in Wad Medani, Sudan, in the period between January and December 2019. Data were collected from patients’ files. OMT was defined as a combination of five medications; aspirin and P2Y12 inhibitors, statins, beta-blockers (BBs), and angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin receptor blockers (ARBs) or if a valid contraindication was documented. RESULTS: Of the 619 patients throughout the study period, 591 were selected based on inclusion and exclusion criteria. The median age of patients was 60 years, and 58.9% of patients were male. Diabetes (44.5%) and hypertension (42%) were the most common risk factors. Most patients (58.4%) were diagnosed with ST-segment elevation myocardial infarction. About 99.7% of patients were on aspirin, 99.5% on statins, 97% on clopidogrel, 96.8% on dual antiplatelet therapy, 70.4% on BBs, and 57.9% on ACEIs/ARBs. OMT for secondary prevention was prescribed to 267 (45.2%) patients with ACS at discharge. CONCLUSION: Although prescriptions for all five guideline-recommended medications after ACS were suboptimal, the study showed a positive trend in prescribing most individual medications. Dove 2022-04-08 /pmc/articles/PMC9005352/ /pubmed/35431548 http://dx.doi.org/10.2147/TCRM.S361129 Text en © 2022 Ahmed et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Ahmed, Kannan O
Ahmed, Ashraf M
Wali, Mojahed B
Ali, Ali H
Azhari, Mustafa M
Babiker, Anas
Yousef, Bashir A
Muddather, Hiba F
Optimal Medical Therapy for Secondary Prevention of Acute Coronary Syndrome: A Retrospective Study from a Tertiary Hospital in Sudan
title Optimal Medical Therapy for Secondary Prevention of Acute Coronary Syndrome: A Retrospective Study from a Tertiary Hospital in Sudan
title_full Optimal Medical Therapy for Secondary Prevention of Acute Coronary Syndrome: A Retrospective Study from a Tertiary Hospital in Sudan
title_fullStr Optimal Medical Therapy for Secondary Prevention of Acute Coronary Syndrome: A Retrospective Study from a Tertiary Hospital in Sudan
title_full_unstemmed Optimal Medical Therapy for Secondary Prevention of Acute Coronary Syndrome: A Retrospective Study from a Tertiary Hospital in Sudan
title_short Optimal Medical Therapy for Secondary Prevention of Acute Coronary Syndrome: A Retrospective Study from a Tertiary Hospital in Sudan
title_sort optimal medical therapy for secondary prevention of acute coronary syndrome: a retrospective study from a tertiary hospital in sudan
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005352/
https://www.ncbi.nlm.nih.gov/pubmed/35431548
http://dx.doi.org/10.2147/TCRM.S361129
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