Human pancreatic microenvironment promotes β-cell differentiation via non-canonical WNT5A/JNK and BMP signaling

In vitro derivation of pancreatic β-cells from human pluripotent stem cells holds promise as diabetes treatment. Despite recent progress, efforts to generate physiologically competent β-cells are still hindered by incomplete understanding of the microenvironment’s role in β-cell development and matu...

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Detalles Bibliográficos
Autores principales: Chmielowiec, Jolanta, Szlachcic, Wojciech J., Yang, Diane, Scavuzzo, Marissa A., Wamble, Katrina, Sarrion-Perdigones, Alejandro, Sabek, Omaima M., Venken, Koen J. T., Borowiak, Malgorzata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005503/
https://www.ncbi.nlm.nih.gov/pubmed/35414140
http://dx.doi.org/10.1038/s41467-022-29646-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005503/
https://www.ncbi.nlm.nih.gov/pubmed/35414140
http://dx.doi.org/10.1038/s41467-022-29646-1

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