A machine learning algorithm with subclonal sensitivity reveals widespread pan-cancer human leukocyte antigen loss of heterozygosity

Human leukocyte antigen loss of heterozygosity (HLA LOH) allows cancer cells to escape immune recognition by deleting HLA alleles, causing the suppressed presentation of tumor neoantigens. Despite its importance in immunotherapy response, few methods exist to detect HLA LOH, and their accuracy is no...

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Detalles Bibliográficos
Autores principales: Pyke, Rachel Marty, Mellacheruvu, Dattatreya, Dea, Steven, Abbott, Charles W., McDaniel, Lee, Bhave, Devayani P., Zhang, Simo V., Levy, Eric, Bartha, Gabor, West, John, Snyder, Michael P., Chen, Richard O., Boyle, Sean Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005524/
https://www.ncbi.nlm.nih.gov/pubmed/35414054
http://dx.doi.org/10.1038/s41467-022-29203-w

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