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Scalp attached tangential magnetoencephalography using tunnel magneto-resistive sensors

Non-invasive human brain functional imaging with millisecond resolution can be achieved only with magnetoencephalography (MEG) and electroencephalography (EEG). MEG has better spatial resolution than EEG because signal distortion due to inhomogeneous head conductivity is negligible in MEG but seriou...

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Autores principales: Kanno, Akitake, Nakasato, Nobukazu, Oogane, Mikihiko, Fujiwara, Kosuke, Nakano, Takafumi, Arimoto, Tadashi, Matsuzaki, Hitoshi, Ando, Yasuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005603/
https://www.ncbi.nlm.nih.gov/pubmed/35414691
http://dx.doi.org/10.1038/s41598-022-10155-6
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author Kanno, Akitake
Nakasato, Nobukazu
Oogane, Mikihiko
Fujiwara, Kosuke
Nakano, Takafumi
Arimoto, Tadashi
Matsuzaki, Hitoshi
Ando, Yasuo
author_facet Kanno, Akitake
Nakasato, Nobukazu
Oogane, Mikihiko
Fujiwara, Kosuke
Nakano, Takafumi
Arimoto, Tadashi
Matsuzaki, Hitoshi
Ando, Yasuo
author_sort Kanno, Akitake
collection PubMed
description Non-invasive human brain functional imaging with millisecond resolution can be achieved only with magnetoencephalography (MEG) and electroencephalography (EEG). MEG has better spatial resolution than EEG because signal distortion due to inhomogeneous head conductivity is negligible in MEG but serious in EEG. However, this advantage has been practically limited by the necessary setback distances between the sensors and scalp, because the Dewar vessel containing liquid helium for superconducting quantum interference devices (SQUIDs) requires a thick vacuum wall. Latest developments of high critical temperature (high-T(c)) SQUIDs or optically pumped magnetometers have allowed closer placement of MEG sensors to the scalp. Here we introduce the use of tunnel magneto-resistive (TMR) sensors for scalp-attached MEG. Improvement of TMR sensitivity with magnetic flux concentrators enabled scalp-tangential MEG at 2.6 mm above the scalp, to target the largest signal component produced by the neural current below. In a healthy subject, our single-channel TMR-MEG system clearly demonstrated the N20m, the initial cortical component of the somatosensory evoked response after median nerve stimulation. Multisite measurement confirmed a spatially and temporally steep peak of N20m, immediately above the source at a latency around 20 ms, indicating a new approach to non-invasive functional brain imaging with millimeter and millisecond resolutions.
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spelling pubmed-90056032022-04-15 Scalp attached tangential magnetoencephalography using tunnel magneto-resistive sensors Kanno, Akitake Nakasato, Nobukazu Oogane, Mikihiko Fujiwara, Kosuke Nakano, Takafumi Arimoto, Tadashi Matsuzaki, Hitoshi Ando, Yasuo Sci Rep Article Non-invasive human brain functional imaging with millisecond resolution can be achieved only with magnetoencephalography (MEG) and electroencephalography (EEG). MEG has better spatial resolution than EEG because signal distortion due to inhomogeneous head conductivity is negligible in MEG but serious in EEG. However, this advantage has been practically limited by the necessary setback distances between the sensors and scalp, because the Dewar vessel containing liquid helium for superconducting quantum interference devices (SQUIDs) requires a thick vacuum wall. Latest developments of high critical temperature (high-T(c)) SQUIDs or optically pumped magnetometers have allowed closer placement of MEG sensors to the scalp. Here we introduce the use of tunnel magneto-resistive (TMR) sensors for scalp-attached MEG. Improvement of TMR sensitivity with magnetic flux concentrators enabled scalp-tangential MEG at 2.6 mm above the scalp, to target the largest signal component produced by the neural current below. In a healthy subject, our single-channel TMR-MEG system clearly demonstrated the N20m, the initial cortical component of the somatosensory evoked response after median nerve stimulation. Multisite measurement confirmed a spatially and temporally steep peak of N20m, immediately above the source at a latency around 20 ms, indicating a new approach to non-invasive functional brain imaging with millimeter and millisecond resolutions. Nature Publishing Group UK 2022-04-12 /pmc/articles/PMC9005603/ /pubmed/35414691 http://dx.doi.org/10.1038/s41598-022-10155-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kanno, Akitake
Nakasato, Nobukazu
Oogane, Mikihiko
Fujiwara, Kosuke
Nakano, Takafumi
Arimoto, Tadashi
Matsuzaki, Hitoshi
Ando, Yasuo
Scalp attached tangential magnetoencephalography using tunnel magneto-resistive sensors
title Scalp attached tangential magnetoencephalography using tunnel magneto-resistive sensors
title_full Scalp attached tangential magnetoencephalography using tunnel magneto-resistive sensors
title_fullStr Scalp attached tangential magnetoencephalography using tunnel magneto-resistive sensors
title_full_unstemmed Scalp attached tangential magnetoencephalography using tunnel magneto-resistive sensors
title_short Scalp attached tangential magnetoencephalography using tunnel magneto-resistive sensors
title_sort scalp attached tangential magnetoencephalography using tunnel magneto-resistive sensors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005603/
https://www.ncbi.nlm.nih.gov/pubmed/35414691
http://dx.doi.org/10.1038/s41598-022-10155-6
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