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QSAR analysis on a large and diverse set of potent phosphoinositide 3-kinase gamma (PI3Kγ) inhibitors using MLR and ANN methods

Phosphorylation of PI3Kγ as a member of lipid kinases-enzymes, plays a crucial role in regulating immune cells through the generation of intracellular signals. Deregulation of this pathway is involved in several tumors. In this research, diverse sets of potent and selective isoform-specific PI3Kγ in...

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Detalles Bibliográficos
Autores principales:	Sadeghi, Fereydoun, Afkhami, Abbas, Madrakian, Tayyebeh, Ghavami, Raouf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005662/ https://www.ncbi.nlm.nih.gov/pubmed/35414065 http://dx.doi.org/10.1038/s41598-022-09843-0

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