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Sensory innervation of the human palmar aponeurosis in healthy individuals and patients with palmar fibromatosis

The human palmar aponeurosis is involved in hand proprioception, and it contains different sensory corpuscle morphotypes that serve this role. In palmar fibromatosis (classically referred to as Dupuytren's disease), the palmar aponeurosis undergoes fibrous structural changes that, presumably, a...

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Autores principales: García‐Martínez, Irene, García‐Mesa, Yolanda, García‐Piqueras, Jorge, Martínez‐Pubil, Antonio, Cobo, Juan L., Feito, Jorge, García‐Suárez, Olivia, Vega, José A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005682/
https://www.ncbi.nlm.nih.gov/pubmed/34881452
http://dx.doi.org/10.1111/joa.13609
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author García‐Martínez, Irene
García‐Mesa, Yolanda
García‐Piqueras, Jorge
Martínez‐Pubil, Antonio
Cobo, Juan L.
Feito, Jorge
García‐Suárez, Olivia
Vega, José A.
author_facet García‐Martínez, Irene
García‐Mesa, Yolanda
García‐Piqueras, Jorge
Martínez‐Pubil, Antonio
Cobo, Juan L.
Feito, Jorge
García‐Suárez, Olivia
Vega, José A.
author_sort García‐Martínez, Irene
collection PubMed
description The human palmar aponeurosis is involved in hand proprioception, and it contains different sensory corpuscle morphotypes that serve this role. In palmar fibromatosis (classically referred to as Dupuytren's disease), the palmar aponeurosis undergoes fibrous structural changes that, presumably, also affect the nervous system, causing altered perception. We analysed the various sensory nerve formation morphotypes in the palmar aponeuroses of healthy subjects and patients with palmar fibromatosis. To do this, we used immunohistochemistry for corpuscular constituents and the putative mechanoproteins PIEZO2 and acid‐sensing ion channel 2. Free nerve endings and Golgi‐Mazzoni, Ruffini, paciniform and Pacinian corpuscles were identified in both the healthy and the pathological conditions. The densities of the free nerve endings and Golgi‐Mazzoni corpuscles were slightly increased in the pathological tissues. Furthermore, the Pacinian corpuscles were enlarged and displayed an altered shape. Finally, there was also morphological and immunohistochemical evidence of occasional denervation of the Pacinian corpuscles, although no increase in their number was observed. Both PIEZO2 and acid‐sensing ion channel 2 were absent from the altered corpuscles. These results indicate that the human palmar aponeurosis is richly innervated, and the free nerve endings and sensory corpuscles within the palmar aponeurosis undergo quantitative and qualitative changes in patients with palmar fibromatosis, which may explain the sensory alterations occasionally reported for this pathology.
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spelling pubmed-90056822022-04-15 Sensory innervation of the human palmar aponeurosis in healthy individuals and patients with palmar fibromatosis García‐Martínez, Irene García‐Mesa, Yolanda García‐Piqueras, Jorge Martínez‐Pubil, Antonio Cobo, Juan L. Feito, Jorge García‐Suárez, Olivia Vega, José A. J Anat Original Papers The human palmar aponeurosis is involved in hand proprioception, and it contains different sensory corpuscle morphotypes that serve this role. In palmar fibromatosis (classically referred to as Dupuytren's disease), the palmar aponeurosis undergoes fibrous structural changes that, presumably, also affect the nervous system, causing altered perception. We analysed the various sensory nerve formation morphotypes in the palmar aponeuroses of healthy subjects and patients with palmar fibromatosis. To do this, we used immunohistochemistry for corpuscular constituents and the putative mechanoproteins PIEZO2 and acid‐sensing ion channel 2. Free nerve endings and Golgi‐Mazzoni, Ruffini, paciniform and Pacinian corpuscles were identified in both the healthy and the pathological conditions. The densities of the free nerve endings and Golgi‐Mazzoni corpuscles were slightly increased in the pathological tissues. Furthermore, the Pacinian corpuscles were enlarged and displayed an altered shape. Finally, there was also morphological and immunohistochemical evidence of occasional denervation of the Pacinian corpuscles, although no increase in their number was observed. Both PIEZO2 and acid‐sensing ion channel 2 were absent from the altered corpuscles. These results indicate that the human palmar aponeurosis is richly innervated, and the free nerve endings and sensory corpuscles within the palmar aponeurosis undergo quantitative and qualitative changes in patients with palmar fibromatosis, which may explain the sensory alterations occasionally reported for this pathology. John Wiley and Sons Inc. 2021-12-08 2022-05 /pmc/articles/PMC9005682/ /pubmed/34881452 http://dx.doi.org/10.1111/joa.13609 Text en © 2021 The Authors. Journal of Anatomy published by John Wiley & Sons Ltd on behalf of Anatomical Society. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Papers
García‐Martínez, Irene
García‐Mesa, Yolanda
García‐Piqueras, Jorge
Martínez‐Pubil, Antonio
Cobo, Juan L.
Feito, Jorge
García‐Suárez, Olivia
Vega, José A.
Sensory innervation of the human palmar aponeurosis in healthy individuals and patients with palmar fibromatosis
title Sensory innervation of the human palmar aponeurosis in healthy individuals and patients with palmar fibromatosis
title_full Sensory innervation of the human palmar aponeurosis in healthy individuals and patients with palmar fibromatosis
title_fullStr Sensory innervation of the human palmar aponeurosis in healthy individuals and patients with palmar fibromatosis
title_full_unstemmed Sensory innervation of the human palmar aponeurosis in healthy individuals and patients with palmar fibromatosis
title_short Sensory innervation of the human palmar aponeurosis in healthy individuals and patients with palmar fibromatosis
title_sort sensory innervation of the human palmar aponeurosis in healthy individuals and patients with palmar fibromatosis
topic Original Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005682/
https://www.ncbi.nlm.nih.gov/pubmed/34881452
http://dx.doi.org/10.1111/joa.13609
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