A rare genetic variant in the cleavage site of prepro-orexin is associated with idiopathic hypersomnia

Idiopathic hypersomnia (IH) is a rare, heterogeneous sleep disorder characterized by excessive daytime sleepiness. In contrast to narcolepsy type 1, which is a well-defined type of central disorders of hypersomnolence, the etiology of IH is poorly understood. No susceptibility loci associated with I...

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Detalles Bibliográficos
Autores principales: Miyagawa, Taku, Tanaka, Susumu, Shimada, Mihoko, Sakai, Noriaki, Tanida, Kotomi, Kotorii, Nozomu, Kotorii, Tatayu, Ariyoshi, Yu, Hashizume, Yuji, Ogi, Kimihiro, Hiejima, Hiroshi, Kanbayashi, Takashi, Imanishi, Aya, Ikegami, Azusa, Kamei, Yuichi, Hida, Akiko, Wada, Yamato, Miyamoto, Masayuki, Takami, Masanori, Kondo, Hideaki, Tamura, Yoshiyuki, Taniyama, Yukari, Omata, Naoto, Mizuno, Tomoyuki, Moriya, Shunpei, Furuya, Hirokazu, Kato, Mitsuhiro, Kato, Kayoko, Ishigooka, Jun, Tsuruta, Kazuhito, Chiba, Shigeru, Yamada, Naoto, Okawa, Masako, Hirata, Koichi, Kuroda, Kenji, Kume, Kazuhiko, Uchimura, Naohisa, Kitada, Masaaki, Kodama, Tohru, Inoue, Yuichi, Nishino, Seiji, Mishima, Kazuo, Tokunaga, Katsushi, Honda, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005711/
https://www.ncbi.nlm.nih.gov/pubmed/35414074
http://dx.doi.org/10.1038/s41525-022-00298-w

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