Systemic bis-phosphinic acid derivative restores chloride transport in Cystic Fibrosis mice

Mutations in the Cystic Fibrosis Transmembrane Conductance Regulator gene (CFTR) are responsible for Cystic Fibrosis (CF). The most common CF-causing mutation is the deletion of the 508th amino-acid of CFTR (F508del), leading to dysregulation of the epithelial fluid transport in the airway’s epithel...

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Detalles Bibliográficos
Autores principales: da Cunha, Mélanie Faria, Pranke, Iwona, Sassi, Ali, Schreiweis, Christiane, Moriceau, Stéphanie, Vidovic, Dragana, Hatton, Aurélie, Carlon, Mariane Sylvia, Creste, Geordie, Berhal, Farouk, Prestat, Guillaume, Freund, Romain, Odolczyk, Norbert, Jais, Jean Philippe, Gravier-Pelletier, Christine, Zielenkiewicz, Piotr, Jullien, Vincent, Hinzpeter, Alexandre, Oury, Franck, Edelman, Aleksander, Sermet-Gaudelus, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005718/
https://www.ncbi.nlm.nih.gov/pubmed/35413967
http://dx.doi.org/10.1038/s41598-022-09678-9

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