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A Response Surface Analysis of the Combination of Dexmedetomidine and Sufentanil for Attenuating the Haemodynamic Response to Endotracheal Intubation
PURPOSE: Dexmedetomidine combined with opioids has been extensively used to blunt cardiovascular responses to endotracheal intubation. To determine their interaction, we aimed to develop a response surface model between dexmedetomidine and sufentanil. METHODS: One hundred and twenty patients undergo...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005746/ https://www.ncbi.nlm.nih.gov/pubmed/35431697 http://dx.doi.org/10.1177/15593258221092367 |
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author | Su, Peng Li, Zheng Jia, Xiaoqian Peng, Xiaoling Liu, Daiqiang Xiao, Jing Tu, Ye Gao, Feng |
author_facet | Su, Peng Li, Zheng Jia, Xiaoqian Peng, Xiaoling Liu, Daiqiang Xiao, Jing Tu, Ye Gao, Feng |
author_sort | Su, Peng |
collection | PubMed |
description | PURPOSE: Dexmedetomidine combined with opioids has been extensively used to blunt cardiovascular responses to endotracheal intubation. To determine their interaction, we aimed to develop a response surface model between dexmedetomidine and sufentanil. METHODS: One hundred and twenty patients undergoing scheduled gynaecological surgery were recruited. According to a simulation of slice design, patients received different dose pairs of dexmedetomidine (0 to 1.1 μg/kg) and sufentanil (.1 to .5 μg/kg). The mean arterial blood pressure and heart rate of patients were recorded just before endotracheal intubation, immediately after intubation, and during the first 3 min after intubation. The primary outcomes were haemodynamic changes. The full dose–response relationship between dexmedetomidine and sufentanil was analysed using a logit model. RESULTS: This response surface model revealed that the interaction between dexmedetomidine and sufentanil was additive. The dose pairs that could effectively attenuate the haemodynamic response to endotracheal intubation primarily ranged from .3 to .4 μg/kg and .5 to 1.1 μg/kg for sufentanil and dexmedetomidine, respectively. CONCLUSION: When used propofol as the main hypnotic drug during anaesthesia induction, dexmedetomidine could effectively reduce the requirement of sufentanil in an additive manner. However, it is not an effective drug for ablating the cardiovascular response to endotracheal intubation when used alone. The clinical trial registry. The trial registry name: Chinese Clinical Trial Registry. Registration number: ChiCTR1800015273. URL:http://www.chictr.org.cn |
format | Online Article Text |
id | pubmed-9005746 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-90057462022-04-14 A Response Surface Analysis of the Combination of Dexmedetomidine and Sufentanil for Attenuating the Haemodynamic Response to Endotracheal Intubation Su, Peng Li, Zheng Jia, Xiaoqian Peng, Xiaoling Liu, Daiqiang Xiao, Jing Tu, Ye Gao, Feng Dose Response Original Article PURPOSE: Dexmedetomidine combined with opioids has been extensively used to blunt cardiovascular responses to endotracheal intubation. To determine their interaction, we aimed to develop a response surface model between dexmedetomidine and sufentanil. METHODS: One hundred and twenty patients undergoing scheduled gynaecological surgery were recruited. According to a simulation of slice design, patients received different dose pairs of dexmedetomidine (0 to 1.1 μg/kg) and sufentanil (.1 to .5 μg/kg). The mean arterial blood pressure and heart rate of patients were recorded just before endotracheal intubation, immediately after intubation, and during the first 3 min after intubation. The primary outcomes were haemodynamic changes. The full dose–response relationship between dexmedetomidine and sufentanil was analysed using a logit model. RESULTS: This response surface model revealed that the interaction between dexmedetomidine and sufentanil was additive. The dose pairs that could effectively attenuate the haemodynamic response to endotracheal intubation primarily ranged from .3 to .4 μg/kg and .5 to 1.1 μg/kg for sufentanil and dexmedetomidine, respectively. CONCLUSION: When used propofol as the main hypnotic drug during anaesthesia induction, dexmedetomidine could effectively reduce the requirement of sufentanil in an additive manner. However, it is not an effective drug for ablating the cardiovascular response to endotracheal intubation when used alone. The clinical trial registry. The trial registry name: Chinese Clinical Trial Registry. Registration number: ChiCTR1800015273. URL:http://www.chictr.org.cn SAGE Publications 2022-04-09 /pmc/articles/PMC9005746/ /pubmed/35431697 http://dx.doi.org/10.1177/15593258221092367 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Article Su, Peng Li, Zheng Jia, Xiaoqian Peng, Xiaoling Liu, Daiqiang Xiao, Jing Tu, Ye Gao, Feng A Response Surface Analysis of the Combination of Dexmedetomidine and Sufentanil for Attenuating the Haemodynamic Response to Endotracheal Intubation |
title | A Response Surface Analysis of the Combination of Dexmedetomidine and
Sufentanil for Attenuating the Haemodynamic Response to Endotracheal
Intubation |
title_full | A Response Surface Analysis of the Combination of Dexmedetomidine and
Sufentanil for Attenuating the Haemodynamic Response to Endotracheal
Intubation |
title_fullStr | A Response Surface Analysis of the Combination of Dexmedetomidine and
Sufentanil for Attenuating the Haemodynamic Response to Endotracheal
Intubation |
title_full_unstemmed | A Response Surface Analysis of the Combination of Dexmedetomidine and
Sufentanil for Attenuating the Haemodynamic Response to Endotracheal
Intubation |
title_short | A Response Surface Analysis of the Combination of Dexmedetomidine and
Sufentanil for Attenuating the Haemodynamic Response to Endotracheal
Intubation |
title_sort | response surface analysis of the combination of dexmedetomidine and
sufentanil for attenuating the haemodynamic response to endotracheal
intubation |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005746/ https://www.ncbi.nlm.nih.gov/pubmed/35431697 http://dx.doi.org/10.1177/15593258221092367 |
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