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Programmed Cell Death Tunes Tumor Immunity
The demise of cells in various ways enables the body to clear unwanted cells. Studies over the years revealed distinctive molecular mechanisms and functional consequences of several key cell death pathways. Currently, the most intensively investigated programmed cell death (PCD) includes apoptosis,...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005769/ https://www.ncbi.nlm.nih.gov/pubmed/35432318 http://dx.doi.org/10.3389/fimmu.2022.847345 |
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author | Liu, Jing Hong, Minjing Li, Yijia Chen, Dan Wu, Yangzhe Hu, Yi |
author_facet | Liu, Jing Hong, Minjing Li, Yijia Chen, Dan Wu, Yangzhe Hu, Yi |
author_sort | Liu, Jing |
collection | PubMed |
description | The demise of cells in various ways enables the body to clear unwanted cells. Studies over the years revealed distinctive molecular mechanisms and functional consequences of several key cell death pathways. Currently, the most intensively investigated programmed cell death (PCD) includes apoptosis, necroptosis, pyroptosis, ferroptosis, PANoptosis, and autophagy, which has been discovered to play crucial roles in modulating the immunosuppressive tumor microenvironment (TME) and determining clinical outcomes of the cancer therapeutic approaches. PCD can play dual roles, either pro-tumor or anti-tumor, partly depending on the intracellular contents released during the process. PCD also regulates the enrichment of effector or regulatory immune cells, thus participating in fine-tuning the anti-tumor immunity in the TME. In this review, we focused primarily on apoptosis, necroptosis, pyroptosis, ferroptosis, PANoptosis, and autophagy, discussed the released molecular messengers participating in regulating their intricate crosstalk with the immune response in the TME, and explored the immunological consequence of PCD and its implications in future cancer therapy developments. |
format | Online Article Text |
id | pubmed-9005769 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90057692022-04-14 Programmed Cell Death Tunes Tumor Immunity Liu, Jing Hong, Minjing Li, Yijia Chen, Dan Wu, Yangzhe Hu, Yi Front Immunol Immunology The demise of cells in various ways enables the body to clear unwanted cells. Studies over the years revealed distinctive molecular mechanisms and functional consequences of several key cell death pathways. Currently, the most intensively investigated programmed cell death (PCD) includes apoptosis, necroptosis, pyroptosis, ferroptosis, PANoptosis, and autophagy, which has been discovered to play crucial roles in modulating the immunosuppressive tumor microenvironment (TME) and determining clinical outcomes of the cancer therapeutic approaches. PCD can play dual roles, either pro-tumor or anti-tumor, partly depending on the intracellular contents released during the process. PCD also regulates the enrichment of effector or regulatory immune cells, thus participating in fine-tuning the anti-tumor immunity in the TME. In this review, we focused primarily on apoptosis, necroptosis, pyroptosis, ferroptosis, PANoptosis, and autophagy, discussed the released molecular messengers participating in regulating their intricate crosstalk with the immune response in the TME, and explored the immunological consequence of PCD and its implications in future cancer therapy developments. Frontiers Media S.A. 2022-03-30 /pmc/articles/PMC9005769/ /pubmed/35432318 http://dx.doi.org/10.3389/fimmu.2022.847345 Text en Copyright © 2022 Liu, Hong, Li, Chen, Wu and Hu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Liu, Jing Hong, Minjing Li, Yijia Chen, Dan Wu, Yangzhe Hu, Yi Programmed Cell Death Tunes Tumor Immunity |
title | Programmed Cell Death Tunes Tumor Immunity |
title_full | Programmed Cell Death Tunes Tumor Immunity |
title_fullStr | Programmed Cell Death Tunes Tumor Immunity |
title_full_unstemmed | Programmed Cell Death Tunes Tumor Immunity |
title_short | Programmed Cell Death Tunes Tumor Immunity |
title_sort | programmed cell death tunes tumor immunity |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005769/ https://www.ncbi.nlm.nih.gov/pubmed/35432318 http://dx.doi.org/10.3389/fimmu.2022.847345 |
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