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CRISPR/Cas9 Approach to Generate an Auxotrophic BCG Strain for Unmarked Expression of LTAK63 Adjuvant: A Tuberculosis Vaccine Candidate

Tuberculosis is one of the deadliest infectious diseases and a huge healthcare burden in many countries. New vaccines, including recombinant BCG-based candidates, are currently under evaluation in clinical trials. Our group previously showed that a recombinant BCG expressing LTAK63 (rBCG-LTAK63), a...

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Detalles Bibliográficos
Autores principales:	Moraes, Luana, Trentini, Monalisa Martins, Fousteris, Dimitrios, Eto, Silas Fernandes, Chudzinski-Tavassi, Ana Marisa, Leite, Luciana Cezar de Cerqueira, Kanno, Alex Issamu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005855/ https://www.ncbi.nlm.nih.gov/pubmed/35432328 http://dx.doi.org/10.3389/fimmu.2022.867195

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