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CARD9 Signaling, Inflammation, and Diseases
Caspase-recruitment domain 9 (CARD9) protein is expressed in many cells especially in immune cells, and is critically involved in the function of the innate and adaptive immune systems through extensive interactions between CARD9 and other signaling molecules including NF-κB and MAPK. CARD9-mediated...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005907/ https://www.ncbi.nlm.nih.gov/pubmed/35432375 http://dx.doi.org/10.3389/fimmu.2022.880879 |
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author | Liu, Xuanyou Jiang, Bimei Hao, Hong Liu, Zhenguo |
author_facet | Liu, Xuanyou Jiang, Bimei Hao, Hong Liu, Zhenguo |
author_sort | Liu, Xuanyou |
collection | PubMed |
description | Caspase-recruitment domain 9 (CARD9) protein is expressed in many cells especially in immune cells, and is critically involved in the function of the innate and adaptive immune systems through extensive interactions between CARD9 and other signaling molecules including NF-κB and MAPK. CARD9-mediated signaling plays a central role in regulating inflammatory responses and oxidative stress through the productions of important cytokines and chemokines. Abnormalities of CARD9 and CARD9 signaling or CARD9 mutations or polymorphism are associated with a variety of pathological conditions including infections, inflammation, and autoimmune disorders. This review focuses on the function of CARD9 and CARD9-mediated signaling pathways, as well as interactions with other important signaling molecules in different cell types and the relations to specific disease conditions including inflammatory diseases, infections, tumorigenesis, and cardiovascular pathologies. |
format | Online Article Text |
id | pubmed-9005907 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90059072022-04-14 CARD9 Signaling, Inflammation, and Diseases Liu, Xuanyou Jiang, Bimei Hao, Hong Liu, Zhenguo Front Immunol Immunology Caspase-recruitment domain 9 (CARD9) protein is expressed in many cells especially in immune cells, and is critically involved in the function of the innate and adaptive immune systems through extensive interactions between CARD9 and other signaling molecules including NF-κB and MAPK. CARD9-mediated signaling plays a central role in regulating inflammatory responses and oxidative stress through the productions of important cytokines and chemokines. Abnormalities of CARD9 and CARD9 signaling or CARD9 mutations or polymorphism are associated with a variety of pathological conditions including infections, inflammation, and autoimmune disorders. This review focuses on the function of CARD9 and CARD9-mediated signaling pathways, as well as interactions with other important signaling molecules in different cell types and the relations to specific disease conditions including inflammatory diseases, infections, tumorigenesis, and cardiovascular pathologies. Frontiers Media S.A. 2022-03-30 /pmc/articles/PMC9005907/ /pubmed/35432375 http://dx.doi.org/10.3389/fimmu.2022.880879 Text en Copyright © 2022 Liu, Jiang, Hao and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Liu, Xuanyou Jiang, Bimei Hao, Hong Liu, Zhenguo CARD9 Signaling, Inflammation, and Diseases |
title | CARD9 Signaling, Inflammation, and Diseases |
title_full | CARD9 Signaling, Inflammation, and Diseases |
title_fullStr | CARD9 Signaling, Inflammation, and Diseases |
title_full_unstemmed | CARD9 Signaling, Inflammation, and Diseases |
title_short | CARD9 Signaling, Inflammation, and Diseases |
title_sort | card9 signaling, inflammation, and diseases |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005907/ https://www.ncbi.nlm.nih.gov/pubmed/35432375 http://dx.doi.org/10.3389/fimmu.2022.880879 |
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