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Functional cross-species conservation of guanylate-binding proteins in innate immunity

Guanylate binding proteins (GBPs) represent an evolutionary ancient protein family widely distributed among eukaryotes. They are interferon (IFN)-inducible guanosine triphosphatases that belong to the dynamin superfamily. GBPs are known to have a major role in the cell-autonomous innate immune respo...

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Autores principales: Schelle, Luca, Côrte-Real, João Vasco, Esteves, Pedro José, Abrantes, Joana, Baldauf, Hanna-Mari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005921/
https://www.ncbi.nlm.nih.gov/pubmed/35416510
http://dx.doi.org/10.1007/s00430-022-00736-7
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author Schelle, Luca
Côrte-Real, João Vasco
Esteves, Pedro José
Abrantes, Joana
Baldauf, Hanna-Mari
author_facet Schelle, Luca
Côrte-Real, João Vasco
Esteves, Pedro José
Abrantes, Joana
Baldauf, Hanna-Mari
author_sort Schelle, Luca
collection PubMed
description Guanylate binding proteins (GBPs) represent an evolutionary ancient protein family widely distributed among eukaryotes. They are interferon (IFN)-inducible guanosine triphosphatases that belong to the dynamin superfamily. GBPs are known to have a major role in the cell-autonomous innate immune response against bacterial, parasitic and viral infections and are also involved in inflammasome activation. Evolutionary studies depicted that GBPs present a pattern of gain and loss of genes in each family with several genes pseudogenized and some genes more divergent, indicative for the birth-and-death evolution process. Most species harbor large GBP gene clusters encoding multiple paralogs. Previous functional studies mainly focused on mouse and human GBPs, but more data are becoming available, broadening the understanding of this multifunctional protein family. In this review, we will provide new insights and give a broad overview about GBP evolution, conservation and their roles in all studied species, including plants, invertebrates and vertebrates, revealing how far the described features of GBPs can be transferred to other species.
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spelling pubmed-90059212022-04-13 Functional cross-species conservation of guanylate-binding proteins in innate immunity Schelle, Luca Côrte-Real, João Vasco Esteves, Pedro José Abrantes, Joana Baldauf, Hanna-Mari Med Microbiol Immunol Review Guanylate binding proteins (GBPs) represent an evolutionary ancient protein family widely distributed among eukaryotes. They are interferon (IFN)-inducible guanosine triphosphatases that belong to the dynamin superfamily. GBPs are known to have a major role in the cell-autonomous innate immune response against bacterial, parasitic and viral infections and are also involved in inflammasome activation. Evolutionary studies depicted that GBPs present a pattern of gain and loss of genes in each family with several genes pseudogenized and some genes more divergent, indicative for the birth-and-death evolution process. Most species harbor large GBP gene clusters encoding multiple paralogs. Previous functional studies mainly focused on mouse and human GBPs, but more data are becoming available, broadening the understanding of this multifunctional protein family. In this review, we will provide new insights and give a broad overview about GBP evolution, conservation and their roles in all studied species, including plants, invertebrates and vertebrates, revealing how far the described features of GBPs can be transferred to other species. Springer Berlin Heidelberg 2022-04-13 2023 /pmc/articles/PMC9005921/ /pubmed/35416510 http://dx.doi.org/10.1007/s00430-022-00736-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Schelle, Luca
Côrte-Real, João Vasco
Esteves, Pedro José
Abrantes, Joana
Baldauf, Hanna-Mari
Functional cross-species conservation of guanylate-binding proteins in innate immunity
title Functional cross-species conservation of guanylate-binding proteins in innate immunity
title_full Functional cross-species conservation of guanylate-binding proteins in innate immunity
title_fullStr Functional cross-species conservation of guanylate-binding proteins in innate immunity
title_full_unstemmed Functional cross-species conservation of guanylate-binding proteins in innate immunity
title_short Functional cross-species conservation of guanylate-binding proteins in innate immunity
title_sort functional cross-species conservation of guanylate-binding proteins in innate immunity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005921/
https://www.ncbi.nlm.nih.gov/pubmed/35416510
http://dx.doi.org/10.1007/s00430-022-00736-7
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