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An Overview of Surgical Treatment of Thymic Epithelial Tumors in Korea: A Retrospective Multicenter Analysis
BACKGROUND: Thymic epithelial tumors (TETs) are rare, and information regarding their surgical outcomes and prognostic factors has rapidly changed in the past few decades. We analyzed surgical treatment practices for TETs and outcomes in terms of overall survival (OS) and freedom from recurrence (FF...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society for Thoracic and Cardiovascular Surgery
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005939/ https://www.ncbi.nlm.nih.gov/pubmed/35370141 http://dx.doi.org/10.5090/jcs.21.124 |
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author | Lee, Jun Oh Lee, Geun Dong Kim, Hyeong Ryul Kim, Dong Kwan Park, Seung-Il Cho, Jong Ho Kim, Hong Kwan Choi, Yong Soo Kim, Jhingook Shim, Young Mog Park, Samina Park, In Kyu Kang, Chang Hyun Kim, Young Tae Park, Seong Yong Lee, Chang Young Lee, Jin Gu Kim, Dae Joon Paik, Hyo Chae |
author_facet | Lee, Jun Oh Lee, Geun Dong Kim, Hyeong Ryul Kim, Dong Kwan Park, Seung-Il Cho, Jong Ho Kim, Hong Kwan Choi, Yong Soo Kim, Jhingook Shim, Young Mog Park, Samina Park, In Kyu Kang, Chang Hyun Kim, Young Tae Park, Seong Yong Lee, Chang Young Lee, Jin Gu Kim, Dae Joon Paik, Hyo Chae |
author_sort | Lee, Jun Oh |
collection | PubMed |
description | BACKGROUND: Thymic epithelial tumors (TETs) are rare, and information regarding their surgical outcomes and prognostic factors has rapidly changed in the past few decades. We analyzed surgical treatment practices for TETs and outcomes in terms of overall survival (OS) and freedom from recurrence (FFR) during a 13-year period in Korea. METHODS: In total, 1,298 patients with surgically resected TETs between 2000 and 2013 were enrolled retrospectively. OS and FFR were calculated using the Kaplan-Meier method and evaluated with the log-rank test. Prognostic factors for OS and FFR were analyzed with multivariable Cox regression. RESULTS: A total of 1,098 patients were diagnosed with thymoma, and 200 patients were diagnosed with thymic carcinoma. Over the study period, the total number of patients with surgically treated TETs and the proportion of patients who underwent minimally invasive thymic surgery (MITS) increased annually. The 5-year and 10-year survival rates of surgically treated TETs were 91.0% and 82.1%, respectively. The 5-year and 10-year recurrence rates were 86.3% and 80.0%, respectively. The outcomes of surgically treated TETs improved over time. Multivariable Cox hazards analysis for OS, age, tumor size, and Masaoka-Koga stage were independent predictors of prognosis. The World Health Organization classification and tumor-node-metastasis (TNM) staging were also related to the prognosis of TETs. CONCLUSION: Surgical treatment of TETs achieved a good prognosis with a recent increase in MITS. The M-K stage was the most important prognostic factor for OS and FFR. The new TNM stage could also be an effective predictor of the outcomes of TETs. |
format | Online Article Text |
id | pubmed-9005939 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Korean Society for Thoracic and Cardiovascular Surgery |
record_format | MEDLINE/PubMed |
spelling | pubmed-90059392022-04-21 An Overview of Surgical Treatment of Thymic Epithelial Tumors in Korea: A Retrospective Multicenter Analysis Lee, Jun Oh Lee, Geun Dong Kim, Hyeong Ryul Kim, Dong Kwan Park, Seung-Il Cho, Jong Ho Kim, Hong Kwan Choi, Yong Soo Kim, Jhingook Shim, Young Mog Park, Samina Park, In Kyu Kang, Chang Hyun Kim, Young Tae Park, Seong Yong Lee, Chang Young Lee, Jin Gu Kim, Dae Joon Paik, Hyo Chae J Chest Surg Clinical Research BACKGROUND: Thymic epithelial tumors (TETs) are rare, and information regarding their surgical outcomes and prognostic factors has rapidly changed in the past few decades. We analyzed surgical treatment practices for TETs and outcomes in terms of overall survival (OS) and freedom from recurrence (FFR) during a 13-year period in Korea. METHODS: In total, 1,298 patients with surgically resected TETs between 2000 and 2013 were enrolled retrospectively. OS and FFR were calculated using the Kaplan-Meier method and evaluated with the log-rank test. Prognostic factors for OS and FFR were analyzed with multivariable Cox regression. RESULTS: A total of 1,098 patients were diagnosed with thymoma, and 200 patients were diagnosed with thymic carcinoma. Over the study period, the total number of patients with surgically treated TETs and the proportion of patients who underwent minimally invasive thymic surgery (MITS) increased annually. The 5-year and 10-year survival rates of surgically treated TETs were 91.0% and 82.1%, respectively. The 5-year and 10-year recurrence rates were 86.3% and 80.0%, respectively. The outcomes of surgically treated TETs improved over time. Multivariable Cox hazards analysis for OS, age, tumor size, and Masaoka-Koga stage were independent predictors of prognosis. The World Health Organization classification and tumor-node-metastasis (TNM) staging were also related to the prognosis of TETs. CONCLUSION: Surgical treatment of TETs achieved a good prognosis with a recent increase in MITS. The M-K stage was the most important prognostic factor for OS and FFR. The new TNM stage could also be an effective predictor of the outcomes of TETs. The Korean Society for Thoracic and Cardiovascular Surgery 2022-04-05 2022-04-05 /pmc/articles/PMC9005939/ /pubmed/35370141 http://dx.doi.org/10.5090/jcs.21.124 Text en Copyright © The Korean Society for Thoracic and Cardiovascular Surgery. 2022. All right reserved. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Research Lee, Jun Oh Lee, Geun Dong Kim, Hyeong Ryul Kim, Dong Kwan Park, Seung-Il Cho, Jong Ho Kim, Hong Kwan Choi, Yong Soo Kim, Jhingook Shim, Young Mog Park, Samina Park, In Kyu Kang, Chang Hyun Kim, Young Tae Park, Seong Yong Lee, Chang Young Lee, Jin Gu Kim, Dae Joon Paik, Hyo Chae An Overview of Surgical Treatment of Thymic Epithelial Tumors in Korea: A Retrospective Multicenter Analysis |
title | An Overview of Surgical Treatment of Thymic Epithelial Tumors in Korea: A Retrospective Multicenter Analysis |
title_full | An Overview of Surgical Treatment of Thymic Epithelial Tumors in Korea: A Retrospective Multicenter Analysis |
title_fullStr | An Overview of Surgical Treatment of Thymic Epithelial Tumors in Korea: A Retrospective Multicenter Analysis |
title_full_unstemmed | An Overview of Surgical Treatment of Thymic Epithelial Tumors in Korea: A Retrospective Multicenter Analysis |
title_short | An Overview of Surgical Treatment of Thymic Epithelial Tumors in Korea: A Retrospective Multicenter Analysis |
title_sort | overview of surgical treatment of thymic epithelial tumors in korea: a retrospective multicenter analysis |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005939/ https://www.ncbi.nlm.nih.gov/pubmed/35370141 http://dx.doi.org/10.5090/jcs.21.124 |
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