Long Non-coding RNA and mRNA Expression Change in Spinal Dorsal Horn After Exercise in Neuropathic Pain Rats

Exercise can help inhibition of neuropathic pain (NP), but the related mechanism remains being explored. In this research, we performed the effect of swimming exercise on the chronic constriction injury (CCI) rats. Compared with CCI group, the mechanical withdrawal threshold of rats in the CCI-Swim...

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Autores principales: Song, Ge, Zhang, Wei-Ming, Wang, Yi-Zu, Guo, Jia-Bao, Zheng, Yi-Li, Yang, Zheng, Su, Xuan, Chen, Yu-Meng, Xie, Qing, Wang, Xue-Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005956/
https://www.ncbi.nlm.nih.gov/pubmed/35431794
http://dx.doi.org/10.3389/fnmol.2022.865310
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author Song, Ge
Zhang, Wei-Ming
Wang, Yi-Zu
Guo, Jia-Bao
Zheng, Yi-Li
Yang, Zheng
Su, Xuan
Chen, Yu-Meng
Xie, Qing
Wang, Xue-Qiang
author_facet Song, Ge
Zhang, Wei-Ming
Wang, Yi-Zu
Guo, Jia-Bao
Zheng, Yi-Li
Yang, Zheng
Su, Xuan
Chen, Yu-Meng
Xie, Qing
Wang, Xue-Qiang
author_sort Song, Ge
collection PubMed
description Exercise can help inhibition of neuropathic pain (NP), but the related mechanism remains being explored. In this research, we performed the effect of swimming exercise on the chronic constriction injury (CCI) rats. Compared with CCI group, the mechanical withdrawal threshold of rats in the CCI-Swim group significantly increased on the 21st and 28th day after CCI surgery. Second-generation RNA-sequencing technology was employed to investigate the transcriptomes of spinal dorsal horns in the Sham, CCI, and CCI-Swim groups. On the 28th day post-operation, 306 intersecting long non-coding RNAs (lncRNAs) and 173 intersecting mRNAs were observed between the CCI vs Sham group and CCI-Swim vs CCI groups. Then, the biological functions of lncRNAs and mRNAs in the spinal dorsal horn of CCI rats were then analyzed. Taking the results together, this study could provide a novel perspective for the treatment for NP.
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spelling pubmed-90059562022-04-14 Long Non-coding RNA and mRNA Expression Change in Spinal Dorsal Horn After Exercise in Neuropathic Pain Rats Song, Ge Zhang, Wei-Ming Wang, Yi-Zu Guo, Jia-Bao Zheng, Yi-Li Yang, Zheng Su, Xuan Chen, Yu-Meng Xie, Qing Wang, Xue-Qiang Front Mol Neurosci Neuroscience Exercise can help inhibition of neuropathic pain (NP), but the related mechanism remains being explored. In this research, we performed the effect of swimming exercise on the chronic constriction injury (CCI) rats. Compared with CCI group, the mechanical withdrawal threshold of rats in the CCI-Swim group significantly increased on the 21st and 28th day after CCI surgery. Second-generation RNA-sequencing technology was employed to investigate the transcriptomes of spinal dorsal horns in the Sham, CCI, and CCI-Swim groups. On the 28th day post-operation, 306 intersecting long non-coding RNAs (lncRNAs) and 173 intersecting mRNAs were observed between the CCI vs Sham group and CCI-Swim vs CCI groups. Then, the biological functions of lncRNAs and mRNAs in the spinal dorsal horn of CCI rats were then analyzed. Taking the results together, this study could provide a novel perspective for the treatment for NP. Frontiers Media S.A. 2022-03-30 /pmc/articles/PMC9005956/ /pubmed/35431794 http://dx.doi.org/10.3389/fnmol.2022.865310 Text en Copyright © 2022 Song, Zhang, Wang, Guo, Zheng, Yang, Su, Chen, Xie and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Song, Ge
Zhang, Wei-Ming
Wang, Yi-Zu
Guo, Jia-Bao
Zheng, Yi-Li
Yang, Zheng
Su, Xuan
Chen, Yu-Meng
Xie, Qing
Wang, Xue-Qiang
Long Non-coding RNA and mRNA Expression Change in Spinal Dorsal Horn After Exercise in Neuropathic Pain Rats
title Long Non-coding RNA and mRNA Expression Change in Spinal Dorsal Horn After Exercise in Neuropathic Pain Rats
title_full Long Non-coding RNA and mRNA Expression Change in Spinal Dorsal Horn After Exercise in Neuropathic Pain Rats
title_fullStr Long Non-coding RNA and mRNA Expression Change in Spinal Dorsal Horn After Exercise in Neuropathic Pain Rats
title_full_unstemmed Long Non-coding RNA and mRNA Expression Change in Spinal Dorsal Horn After Exercise in Neuropathic Pain Rats
title_short Long Non-coding RNA and mRNA Expression Change in Spinal Dorsal Horn After Exercise in Neuropathic Pain Rats
title_sort long non-coding rna and mrna expression change in spinal dorsal horn after exercise in neuropathic pain rats
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005956/
https://www.ncbi.nlm.nih.gov/pubmed/35431794
http://dx.doi.org/10.3389/fnmol.2022.865310
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