Cargando…

Vascular Co-Option and Other Alternative Modalities of Growth of Tumor Vasculature in Glioblastoma

Non-angiogenic tumors grow in the absence of angiogenesis by two main mechanisms: cancer cells infiltrating and occupying the normal tissues to exploit pre-existing vessels (vascular co-option); the cancer cells themselves forms channels able to provide blood flow (the so called vasculogenic mimicry...

Descripción completa

Detalles Bibliográficos
Autores principales: Ribatti, Domenico, Pezzella, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005970/
https://www.ncbi.nlm.nih.gov/pubmed/35433447
http://dx.doi.org/10.3389/fonc.2022.874554
_version_ 1784686574323105792
author Ribatti, Domenico
Pezzella, Francesco
author_facet Ribatti, Domenico
Pezzella, Francesco
author_sort Ribatti, Domenico
collection PubMed
description Non-angiogenic tumors grow in the absence of angiogenesis by two main mechanisms: cancer cells infiltrating and occupying the normal tissues to exploit pre-existing vessels (vascular co-option); the cancer cells themselves forms channels able to provide blood flow (the so called vasculogenic mimicry). In the original work on vascular co-option initiated by Francesco Pezzella, the non-angiogenic cancer cells were described as “exploiting” pre-existing vessels. Vascular co-option has been described in primary and secondary (metastatic) sites. Vascular co-option is defined as a process in which tumor cells interact with and exploit the pre-existing vasculature of the normal tissue in which they grow. As part of this process, cancer cells first migrate toward vessels of the primary tumor, or extravasate at a metastatic site and rest along the ab-luminal vascular surface. The second hallmark of vascular co-option is the interaction of cancer cells with the ab-luminal vascular surface. The first evidence for this was provided in a rat C6 glioblastoma model, showing that the initial tumor growth phase was not always avascular as these initial tumors can be vascularized by pre-existing vessels. The aim of this review article is to analyze together with vascular co-option, other alternative mode of vascularization occurring in glioblastoma multiforme (GBM), including vasculogenic mimicry, angiotropism and trans-differentiation of glioblastoma stem cells.
format Online
Article
Text
id pubmed-9005970
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-90059702022-04-14 Vascular Co-Option and Other Alternative Modalities of Growth of Tumor Vasculature in Glioblastoma Ribatti, Domenico Pezzella, Francesco Front Oncol Oncology Non-angiogenic tumors grow in the absence of angiogenesis by two main mechanisms: cancer cells infiltrating and occupying the normal tissues to exploit pre-existing vessels (vascular co-option); the cancer cells themselves forms channels able to provide blood flow (the so called vasculogenic mimicry). In the original work on vascular co-option initiated by Francesco Pezzella, the non-angiogenic cancer cells were described as “exploiting” pre-existing vessels. Vascular co-option has been described in primary and secondary (metastatic) sites. Vascular co-option is defined as a process in which tumor cells interact with and exploit the pre-existing vasculature of the normal tissue in which they grow. As part of this process, cancer cells first migrate toward vessels of the primary tumor, or extravasate at a metastatic site and rest along the ab-luminal vascular surface. The second hallmark of vascular co-option is the interaction of cancer cells with the ab-luminal vascular surface. The first evidence for this was provided in a rat C6 glioblastoma model, showing that the initial tumor growth phase was not always avascular as these initial tumors can be vascularized by pre-existing vessels. The aim of this review article is to analyze together with vascular co-option, other alternative mode of vascularization occurring in glioblastoma multiforme (GBM), including vasculogenic mimicry, angiotropism and trans-differentiation of glioblastoma stem cells. Frontiers Media S.A. 2022-03-30 /pmc/articles/PMC9005970/ /pubmed/35433447 http://dx.doi.org/10.3389/fonc.2022.874554 Text en Copyright © 2022 Ribatti and Pezzella https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Ribatti, Domenico
Pezzella, Francesco
Vascular Co-Option and Other Alternative Modalities of Growth of Tumor Vasculature in Glioblastoma
title Vascular Co-Option and Other Alternative Modalities of Growth of Tumor Vasculature in Glioblastoma
title_full Vascular Co-Option and Other Alternative Modalities of Growth of Tumor Vasculature in Glioblastoma
title_fullStr Vascular Co-Option and Other Alternative Modalities of Growth of Tumor Vasculature in Glioblastoma
title_full_unstemmed Vascular Co-Option and Other Alternative Modalities of Growth of Tumor Vasculature in Glioblastoma
title_short Vascular Co-Option and Other Alternative Modalities of Growth of Tumor Vasculature in Glioblastoma
title_sort vascular co-option and other alternative modalities of growth of tumor vasculature in glioblastoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005970/
https://www.ncbi.nlm.nih.gov/pubmed/35433447
http://dx.doi.org/10.3389/fonc.2022.874554
work_keys_str_mv AT ribattidomenico vascularcooptionandotheralternativemodalitiesofgrowthoftumorvasculatureinglioblastoma
AT pezzellafrancesco vascularcooptionandotheralternativemodalitiesofgrowthoftumorvasculatureinglioblastoma