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Automated Synthesis of (18)F-BCPP-EF {2-tert-Butyl-4-Chloro-5-{6-[2-(2[(18)F]fluoroethoxy)-Ethoxy]-Pyridin-3-ylmethoxy}-2H-Pyridazin-3-One for Imaging of Mitochondrial Complex 1 in Parkinson’s Disease

Mitochondrial complex I (MC-I) is an essential component of brain bioenergetics and can be quantified and studied using positron emission tomography (PET). A specific high affinity (18)F radiotracer for MC-I enables monitoring of neurodegenerative disease progression and pathology via PET imaging. T...

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Detalles Bibliográficos
Autores principales:	Kaur, Tanpreet, Brooks, Allen F., Liddell, Katherine M., Henderson, Bradford D., Hockley, Brian G., Bohnen, Nicolaas I., Albin, Roger L., Scott, Peter J. H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005973/ https://www.ncbi.nlm.nih.gov/pubmed/35433631 http://dx.doi.org/10.3389/fchem.2022.878835

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