Recurrence in Plasmodium vivax malaria: a prospective cohort study with long follow-up from a coastal region in South-West India

Background:  India is endemic for Plasmodium vivax (Pv) malaria. Despite a decrease in incidence, its elimination is hampered by recurrences. This study aimed to characterize recurrences in Pv malaria and study its association with primaquine (PQ) usage. Methods:  Symptomatic adult Pv patients were...

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Detalles Bibliográficos
Autores principales: Gandrala, Divya, Gupta, Nitin, Lavu, Alekhya, Nallapati, Vishnu Teja, Guddattu, Vasudeva, Saravu, Kavitha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005986/
https://www.ncbi.nlm.nih.gov/pubmed/35464047
http://dx.doi.org/10.12688/f1000research.109577.2
Descripción
Sumario:Background:  India is endemic for Plasmodium vivax (Pv) malaria. Despite a decrease in incidence, its elimination is hampered by recurrences. This study aimed to characterize recurrences in Pv malaria and study its association with primaquine (PQ) usage. Methods:  Symptomatic adult Pv patients were followed-up for up to 23 months for recurrences. The time to recurrence was compared by the PQ dosage they received using a log-rank test. Results: Of the 294 malaria patients, 206 (70%) patients had Pv infection during the study period. A total of 20 (9.7%) recurrences were seen in 17 (8.2%) patients of Pv. The percentage of first-time recurrences were highest in the no PQ group (25%), followed by the weekly PQ group (20%), low dose daily PQ (8.2%) group, and high dose daily PQ group (3.1%). Conclusions: Recurrence in Pv malaria is common, especially in those who receive an incorrect prescription of primaquine.

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