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Recurrence in Plasmodium vivax malaria: a prospective cohort study with long follow-up from a coastal region in South-West India
Background: India is endemic for Plasmodium vivax (Pv) malaria. Despite a decrease in incidence, its elimination is hampered by recurrences. This study aimed to characterize recurrences in Pv malaria and study its association with primaquine (PQ) usage. Methods: Symptomatic adult Pv patients were...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000 Research Limited
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005986/ https://www.ncbi.nlm.nih.gov/pubmed/35464047 http://dx.doi.org/10.12688/f1000research.109577.2 |
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author | Gandrala, Divya Gupta, Nitin Lavu, Alekhya Nallapati, Vishnu Teja Guddattu, Vasudeva Saravu, Kavitha |
author_facet | Gandrala, Divya Gupta, Nitin Lavu, Alekhya Nallapati, Vishnu Teja Guddattu, Vasudeva Saravu, Kavitha |
author_sort | Gandrala, Divya |
collection | PubMed |
description | Background: India is endemic for Plasmodium vivax (Pv) malaria. Despite a decrease in incidence, its elimination is hampered by recurrences. This study aimed to characterize recurrences in Pv malaria and study its association with primaquine (PQ) usage. Methods: Symptomatic adult Pv patients were followed-up for up to 23 months for recurrences. The time to recurrence was compared by the PQ dosage they received using a log-rank test. Results: Of the 294 malaria patients, 206 (70%) patients had Pv infection during the study period. A total of 20 (9.7%) recurrences were seen in 17 (8.2%) patients of Pv. The percentage of first-time recurrences were highest in the no PQ group (25%), followed by the weekly PQ group (20%), low dose daily PQ (8.2%) group, and high dose daily PQ group (3.1%). Conclusions: Recurrence in Pv malaria is common, especially in those who receive an incorrect prescription of primaquine. |
format | Online Article Text |
id | pubmed-9005986 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | F1000 Research Limited |
record_format | MEDLINE/PubMed |
spelling | pubmed-90059862022-04-21 Recurrence in Plasmodium vivax malaria: a prospective cohort study with long follow-up from a coastal region in South-West India Gandrala, Divya Gupta, Nitin Lavu, Alekhya Nallapati, Vishnu Teja Guddattu, Vasudeva Saravu, Kavitha F1000Res Research Article Background: India is endemic for Plasmodium vivax (Pv) malaria. Despite a decrease in incidence, its elimination is hampered by recurrences. This study aimed to characterize recurrences in Pv malaria and study its association with primaquine (PQ) usage. Methods: Symptomatic adult Pv patients were followed-up for up to 23 months for recurrences. The time to recurrence was compared by the PQ dosage they received using a log-rank test. Results: Of the 294 malaria patients, 206 (70%) patients had Pv infection during the study period. A total of 20 (9.7%) recurrences were seen in 17 (8.2%) patients of Pv. The percentage of first-time recurrences were highest in the no PQ group (25%), followed by the weekly PQ group (20%), low dose daily PQ (8.2%) group, and high dose daily PQ group (3.1%). Conclusions: Recurrence in Pv malaria is common, especially in those who receive an incorrect prescription of primaquine. F1000 Research Limited 2022-04-06 /pmc/articles/PMC9005986/ /pubmed/35464047 http://dx.doi.org/10.12688/f1000research.109577.2 Text en Copyright: © 2022 Gandrala D et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Gandrala, Divya Gupta, Nitin Lavu, Alekhya Nallapati, Vishnu Teja Guddattu, Vasudeva Saravu, Kavitha Recurrence in Plasmodium vivax malaria: a prospective cohort study with long follow-up from a coastal region in South-West India |
title | Recurrence in
Plasmodium vivax malaria: a prospective cohort study with long follow-up from a coastal region in South-West India |
title_full | Recurrence in
Plasmodium vivax malaria: a prospective cohort study with long follow-up from a coastal region in South-West India |
title_fullStr | Recurrence in
Plasmodium vivax malaria: a prospective cohort study with long follow-up from a coastal region in South-West India |
title_full_unstemmed | Recurrence in
Plasmodium vivax malaria: a prospective cohort study with long follow-up from a coastal region in South-West India |
title_short | Recurrence in
Plasmodium vivax malaria: a prospective cohort study with long follow-up from a coastal region in South-West India |
title_sort | recurrence in
plasmodium vivax malaria: a prospective cohort study with long follow-up from a coastal region in south-west india |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005986/ https://www.ncbi.nlm.nih.gov/pubmed/35464047 http://dx.doi.org/10.12688/f1000research.109577.2 |
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