Possible roles of N- and C-terminal unstructured tails of CPI-17 in regulating Ca(2+) sensitization force of smooth muscle

CPI-17 regulates the myosin phosphatase and mediates the agonist-induced contraction of smooth muscle. PKC and ROCK phosphorylate CPI-17 at Thr38 leading to a conformational change of the central inhibitory domain (PHIN domain). The N- and C-terminal tails of CPI-17 are predicted as unstructured loo...

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Detalles Bibliográficos
Autores principales: Eto, Masumi, Katsuki, Shuichi, Ohashi, Minami, Miyagawa, Yui, Tanaka, Yoshinori, Takeya, Kosuke, Kitazawa, Toshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Society of Smooth Muscle Research 2022
Materias:
Original
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006046/
https://www.ncbi.nlm.nih.gov/pubmed/35418530
http://dx.doi.org/10.1540/jsmr.58.22

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