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Integrated Analysis of Genes Associated With Immune Microenvironment and Distant Metastasis in Uveal Melanoma

Inflammatory infiltration plays an essential role in the progression of tumor malignancy. The aim of this study was to identify genes associated with inflammatory microenvironment and clinical traits for survival prediction of uveal melanoma (UVM) patients. The datasets and clinical characteristics...

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Autores principales: Zhou, Wenchuan, Li, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006059/
https://www.ncbi.nlm.nih.gov/pubmed/35433689
http://dx.doi.org/10.3389/fcell.2022.874839
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author Zhou, Wenchuan
Li, Jing
author_facet Zhou, Wenchuan
Li, Jing
author_sort Zhou, Wenchuan
collection PubMed
description Inflammatory infiltration plays an essential role in the progression of tumor malignancy. The aim of this study was to identify genes associated with inflammatory microenvironment and clinical traits for survival prediction of uveal melanoma (UVM) patients. The datasets and clinical characteristics of UVM were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. We divided the UVM patients into low and high immune cell infiltration groups, identified differentially expressed genes (DEGs), constructed weighted gene co-expression network, and established prognostic prediction model and nomogram for UVM. Our analysis showed that DEGs were enriched in cytokine signaling in immune system, positive regulation of immune response and adaptive immune system. A total of fifteen candidate genes were extracted from DEGs and genes that were positively associated with tumor metastasis. Subsequently, five prognostic genes were selected to construct the final prognostic prediction model, including two up-regulated genes LHFPL3 antisense RNA 1 (LHFPL3-AS1) and LYN proto-oncogene (LYN), and three down-regulated genes SLCO4A1 antisense RNA 1 (SLCO4A1-AS1), Zinc-α2-glycoprotein 1 (AZGP1) and Deleted in Liver Cancer-1 (DLC1) in the high risk group. The model showed an Area Under Curve (AUC) value of 0.877. Our analysis highlighted the importance of immune-related genes in the progression of UVM and also provided potential targets for the immunotherapy of UVM.
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spelling pubmed-90060592022-04-14 Integrated Analysis of Genes Associated With Immune Microenvironment and Distant Metastasis in Uveal Melanoma Zhou, Wenchuan Li, Jing Front Cell Dev Biol Cell and Developmental Biology Inflammatory infiltration plays an essential role in the progression of tumor malignancy. The aim of this study was to identify genes associated with inflammatory microenvironment and clinical traits for survival prediction of uveal melanoma (UVM) patients. The datasets and clinical characteristics of UVM were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. We divided the UVM patients into low and high immune cell infiltration groups, identified differentially expressed genes (DEGs), constructed weighted gene co-expression network, and established prognostic prediction model and nomogram for UVM. Our analysis showed that DEGs were enriched in cytokine signaling in immune system, positive regulation of immune response and adaptive immune system. A total of fifteen candidate genes were extracted from DEGs and genes that were positively associated with tumor metastasis. Subsequently, five prognostic genes were selected to construct the final prognostic prediction model, including two up-regulated genes LHFPL3 antisense RNA 1 (LHFPL3-AS1) and LYN proto-oncogene (LYN), and three down-regulated genes SLCO4A1 antisense RNA 1 (SLCO4A1-AS1), Zinc-α2-glycoprotein 1 (AZGP1) and Deleted in Liver Cancer-1 (DLC1) in the high risk group. The model showed an Area Under Curve (AUC) value of 0.877. Our analysis highlighted the importance of immune-related genes in the progression of UVM and also provided potential targets for the immunotherapy of UVM. Frontiers Media S.A. 2022-03-30 /pmc/articles/PMC9006059/ /pubmed/35433689 http://dx.doi.org/10.3389/fcell.2022.874839 Text en Copyright © 2022 Zhou and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Zhou, Wenchuan
Li, Jing
Integrated Analysis of Genes Associated With Immune Microenvironment and Distant Metastasis in Uveal Melanoma
title Integrated Analysis of Genes Associated With Immune Microenvironment and Distant Metastasis in Uveal Melanoma
title_full Integrated Analysis of Genes Associated With Immune Microenvironment and Distant Metastasis in Uveal Melanoma
title_fullStr Integrated Analysis of Genes Associated With Immune Microenvironment and Distant Metastasis in Uveal Melanoma
title_full_unstemmed Integrated Analysis of Genes Associated With Immune Microenvironment and Distant Metastasis in Uveal Melanoma
title_short Integrated Analysis of Genes Associated With Immune Microenvironment and Distant Metastasis in Uveal Melanoma
title_sort integrated analysis of genes associated with immune microenvironment and distant metastasis in uveal melanoma
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006059/
https://www.ncbi.nlm.nih.gov/pubmed/35433689
http://dx.doi.org/10.3389/fcell.2022.874839
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