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Phage-mediated horizontal gene transfer and its implications for the human gut microbiome
Horizontal gene transfer (HGT) in the microbiome has profound consequences for human health and disease. The spread of antibiotic resistance genes, virulence, and pathogenicity determinants predominantly occurs by way of HGT. Evidence exists of extensive horizontal transfer in the human gut microbio...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006064/ https://www.ncbi.nlm.nih.gov/pubmed/35425613 http://dx.doi.org/10.1093/gastro/goac012 |
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author | Borodovich, Tatiana Shkoporov, Andrey N Ross, R Paul Hill, Colin |
author_facet | Borodovich, Tatiana Shkoporov, Andrey N Ross, R Paul Hill, Colin |
author_sort | Borodovich, Tatiana |
collection | PubMed |
description | Horizontal gene transfer (HGT) in the microbiome has profound consequences for human health and disease. The spread of antibiotic resistance genes, virulence, and pathogenicity determinants predominantly occurs by way of HGT. Evidence exists of extensive horizontal transfer in the human gut microbiome. Phage transduction is a type of HGT event in which a bacteriophage transfers non-viral DNA from one bacterial host cell to another. The abundance of tailed bacteriophages in the human gut suggests that transduction could act as a significant mode of HGT in the gut microbiome. Here we review in detail the known mechanisms of phage-mediated HGT, namely specialized and generalized transduction, lateral transduction, gene-transfer agents, and molecular piracy, as well as methods used to detect phage-mediated HGT, and discuss its potential implications for the human gut microbiome. |
format | Online Article Text |
id | pubmed-9006064 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-90060642022-04-13 Phage-mediated horizontal gene transfer and its implications for the human gut microbiome Borodovich, Tatiana Shkoporov, Andrey N Ross, R Paul Hill, Colin Gastroenterol Rep (Oxf) Review Article Horizontal gene transfer (HGT) in the microbiome has profound consequences for human health and disease. The spread of antibiotic resistance genes, virulence, and pathogenicity determinants predominantly occurs by way of HGT. Evidence exists of extensive horizontal transfer in the human gut microbiome. Phage transduction is a type of HGT event in which a bacteriophage transfers non-viral DNA from one bacterial host cell to another. The abundance of tailed bacteriophages in the human gut suggests that transduction could act as a significant mode of HGT in the gut microbiome. Here we review in detail the known mechanisms of phage-mediated HGT, namely specialized and generalized transduction, lateral transduction, gene-transfer agents, and molecular piracy, as well as methods used to detect phage-mediated HGT, and discuss its potential implications for the human gut microbiome. Oxford University Press 2022-04-13 /pmc/articles/PMC9006064/ /pubmed/35425613 http://dx.doi.org/10.1093/gastro/goac012 Text en © The Author(s) 2022. Published by Oxford University Press and Sixth Affiliated Hospital of Sun Yat-sen University https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Borodovich, Tatiana Shkoporov, Andrey N Ross, R Paul Hill, Colin Phage-mediated horizontal gene transfer and its implications for the human gut microbiome |
title | Phage-mediated horizontal gene transfer and its implications for the human gut microbiome |
title_full | Phage-mediated horizontal gene transfer and its implications for the human gut microbiome |
title_fullStr | Phage-mediated horizontal gene transfer and its implications for the human gut microbiome |
title_full_unstemmed | Phage-mediated horizontal gene transfer and its implications for the human gut microbiome |
title_short | Phage-mediated horizontal gene transfer and its implications for the human gut microbiome |
title_sort | phage-mediated horizontal gene transfer and its implications for the human gut microbiome |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006064/ https://www.ncbi.nlm.nih.gov/pubmed/35425613 http://dx.doi.org/10.1093/gastro/goac012 |
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