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Phage-mediated horizontal gene transfer and its implications for the human gut microbiome

Horizontal gene transfer (HGT) in the microbiome has profound consequences for human health and disease. The spread of antibiotic resistance genes, virulence, and pathogenicity determinants predominantly occurs by way of HGT. Evidence exists of extensive horizontal transfer in the human gut microbio...

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Detalles Bibliográficos
Autores principales: Borodovich, Tatiana, Shkoporov, Andrey N, Ross, R Paul, Hill, Colin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006064/
https://www.ncbi.nlm.nih.gov/pubmed/35425613
http://dx.doi.org/10.1093/gastro/goac012
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author Borodovich, Tatiana
Shkoporov, Andrey N
Ross, R Paul
Hill, Colin
author_facet Borodovich, Tatiana
Shkoporov, Andrey N
Ross, R Paul
Hill, Colin
author_sort Borodovich, Tatiana
collection PubMed
description Horizontal gene transfer (HGT) in the microbiome has profound consequences for human health and disease. The spread of antibiotic resistance genes, virulence, and pathogenicity determinants predominantly occurs by way of HGT. Evidence exists of extensive horizontal transfer in the human gut microbiome. Phage transduction is a type of HGT event in which a bacteriophage transfers non-viral DNA from one bacterial host cell to another. The abundance of tailed bacteriophages in the human gut suggests that transduction could act as a significant mode of HGT in the gut microbiome. Here we review in detail the known mechanisms of phage-mediated HGT, namely specialized and generalized transduction, lateral transduction, gene-transfer agents, and molecular piracy, as well as methods used to detect phage-mediated HGT, and discuss its potential implications for the human gut microbiome.
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spelling pubmed-90060642022-04-13 Phage-mediated horizontal gene transfer and its implications for the human gut microbiome Borodovich, Tatiana Shkoporov, Andrey N Ross, R Paul Hill, Colin Gastroenterol Rep (Oxf) Review Article Horizontal gene transfer (HGT) in the microbiome has profound consequences for human health and disease. The spread of antibiotic resistance genes, virulence, and pathogenicity determinants predominantly occurs by way of HGT. Evidence exists of extensive horizontal transfer in the human gut microbiome. Phage transduction is a type of HGT event in which a bacteriophage transfers non-viral DNA from one bacterial host cell to another. The abundance of tailed bacteriophages in the human gut suggests that transduction could act as a significant mode of HGT in the gut microbiome. Here we review in detail the known mechanisms of phage-mediated HGT, namely specialized and generalized transduction, lateral transduction, gene-transfer agents, and molecular piracy, as well as methods used to detect phage-mediated HGT, and discuss its potential implications for the human gut microbiome. Oxford University Press 2022-04-13 /pmc/articles/PMC9006064/ /pubmed/35425613 http://dx.doi.org/10.1093/gastro/goac012 Text en © The Author(s) 2022. Published by Oxford University Press and Sixth Affiliated Hospital of Sun Yat-sen University https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Borodovich, Tatiana
Shkoporov, Andrey N
Ross, R Paul
Hill, Colin
Phage-mediated horizontal gene transfer and its implications for the human gut microbiome
title Phage-mediated horizontal gene transfer and its implications for the human gut microbiome
title_full Phage-mediated horizontal gene transfer and its implications for the human gut microbiome
title_fullStr Phage-mediated horizontal gene transfer and its implications for the human gut microbiome
title_full_unstemmed Phage-mediated horizontal gene transfer and its implications for the human gut microbiome
title_short Phage-mediated horizontal gene transfer and its implications for the human gut microbiome
title_sort phage-mediated horizontal gene transfer and its implications for the human gut microbiome
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006064/
https://www.ncbi.nlm.nih.gov/pubmed/35425613
http://dx.doi.org/10.1093/gastro/goac012
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