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Antigen-specific immunotherapy with apitopes suppresses generation of FVIII inhibitor antibodies in HLA-transgenic mice

Hemophilia A (HA) is a blood clotting disorder that is caused by various genetic deficiencies in the factor VIII (FVIII)-encoding F8 gene. Patients receiving FVIII-replacement therapy are at risk for developing neutralizing antibodies (FVIII inhibitors), rendering the FVIII-replacement therapy ineff...

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Detalles Bibliográficos
Autores principales:	Pletinckx, Katrien, Nicolson, Kirsty S., Streeter, Heather B., Sanderson, William J., Schurgers, Evelien, Jansson, Lotta, Wraith, David C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Hematology 2022
Materias:	Immunobiology and Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006293/ https://www.ncbi.nlm.nih.gov/pubmed/34529764 http://dx.doi.org/10.1182/bloodadvances.2021004451

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