CCR2/CCR5 inhibitor permits the radiation-induced effector T cell infiltration in pancreatic adenocarcinoma

The resistance of pancreatic ductal adenocarcinoma (PDAC) to immune checkpoint inhibitors (ICIs) is attributed to the immune-quiescent and -suppressive tumor microenvironment (TME). We recently found that CCR2 and CCR5 were induced in PDAC following treatment with anti–PD-1 antibody (αPD-1); thus, w...

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Detalles Bibliográficos
Autores principales: Wang, Jianxin, Saung, May Tun, Li, Keyu, Fu, Juan, Fujiwara, Kenji, Niu, Nan, Muth, Stephen, Wang, Junke, Xu, Yao, Rozich, Noah, Zlomke, Haley, Chen, Sophia, Espinoza, Birginia, Henderson, MacKenzie, Funes, Vanessa, Herbst, Brian, Ding, Ding, Twyman-Saint Victor, Christina, Zhao, Qihong, Narang, Amol, He, Jin, Zheng, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006312/
https://www.ncbi.nlm.nih.gov/pubmed/35404390
http://dx.doi.org/10.1084/jem.20211631

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