Evaluation of rapid antigen detection kits for detection of SARS-CoV-2 B.1.617.2 virus

Aim: Currently, there is lack of data regarding rapid antigen detection (RAD) kits to detect SARS-CoV-2 B.1.617.2 virus. Objective: The purpose of this evaluation is to assess analytical sensitivity of 12 RAD kits against SARS-CoV-2 B.1.617.2. Study design: Analytical sensitivity was determined by l...

Descripción completa

Detalles Bibliográficos
Autores principales: Mak, Gannon CK, Lau, Stephen SY, Wong, Kitty KY, Chow, Nancy LS, Lau, Chi-Shan, Lam, Edman TK, Ng, Ken HL, Chan, Rickjason CW
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006337/
https://www.ncbi.nlm.nih.gov/pubmed/35432576
http://dx.doi.org/10.2217/fvl-2021-0229
Descripción
Sumario:Aim: Currently, there is lack of data regarding rapid antigen detection (RAD) kits to detect SARS-CoV-2 B.1.617.2 virus. Objective: The purpose of this evaluation is to assess analytical sensitivity of 12 RAD kits against SARS-CoV-2 B.1.617.2. Study design: Analytical sensitivity was determined by limit of detection (LOD). A serial tenfold dilution set from a respiratory specimen collected from a COVID-19 patient infected by SARS-CoV-2 B.1.617.2 was used. RT-PCR was used as a reference method. Results: The LOD results showed that 11 and one RAD kits were 100- and 1000-fold less sensitive than RT-PCR respectively. Conclusion: The results showed that the RAD kits evaluated in this study may be used for first-line screening of the SARS-CoV-2 B.1.617.2 variant.

Ejemplares similares