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Interferons in coronavirus pathogenesis: The good, the bad, and the ugly
Interferons (IFNs) are a key component of the innate antiviral immunity and are generally implicated in protective host immune responses. Here, I discuss the central role of IFNs during different coronavirus (CoV) infections, the importance of timing of the IFN response, and how emerging human coron...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier Inc.
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006388/ https://www.ncbi.nlm.nih.gov/pubmed/35421336 http://dx.doi.org/10.1016/j.chom.2022.03.022 |
| _version_ | 1784686654770905088 |
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| author | Channappanavar, Rudragouda |
| author_facet | Channappanavar, Rudragouda |
| author_sort | Channappanavar, Rudragouda |
| collection | PubMed |
| description | Interferons (IFNs) are a key component of the innate antiviral immunity and are generally implicated in protective host immune responses. Here, I discuss the central role of IFNs during different coronavirus (CoV) infections, the importance of timing of the IFN response, and how emerging human coronaviruses subvert antiviral IFN response to cause severe disease. |
| format | Online Article Text |
| id | pubmed-9006388 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Elsevier Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-90063882022-04-13 Interferons in coronavirus pathogenesis: The good, the bad, and the ugly Channappanavar, Rudragouda Cell Host Microbe Commentary Interferons (IFNs) are a key component of the innate antiviral immunity and are generally implicated in protective host immune responses. Here, I discuss the central role of IFNs during different coronavirus (CoV) infections, the importance of timing of the IFN response, and how emerging human coronaviruses subvert antiviral IFN response to cause severe disease. Elsevier Inc. 2022-04-13 2022-04-13 /pmc/articles/PMC9006388/ /pubmed/35421336 http://dx.doi.org/10.1016/j.chom.2022.03.022 Text en © 2022 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
| spellingShingle | Commentary Channappanavar, Rudragouda Interferons in coronavirus pathogenesis: The good, the bad, and the ugly |
| title | Interferons in coronavirus pathogenesis: The good, the bad, and the ugly |
| title_full | Interferons in coronavirus pathogenesis: The good, the bad, and the ugly |
| title_fullStr | Interferons in coronavirus pathogenesis: The good, the bad, and the ugly |
| title_full_unstemmed | Interferons in coronavirus pathogenesis: The good, the bad, and the ugly |
| title_short | Interferons in coronavirus pathogenesis: The good, the bad, and the ugly |
| title_sort | interferons in coronavirus pathogenesis: the good, the bad, and the ugly |
| topic | Commentary |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006388/ https://www.ncbi.nlm.nih.gov/pubmed/35421336 http://dx.doi.org/10.1016/j.chom.2022.03.022 |
| work_keys_str_mv | AT channappanavarrudragouda interferonsincoronaviruspathogenesisthegoodthebadandtheugly |